PMID- 23888094
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130726
LR  - 20211021
IS  - 0973-2063 (Print)
IS  - 0973-2063 (Electronic)
IS  - 0973-2063 (Linking)
VI  - 9
IP  - 11
DP  - 2013
TI  - Views and opinion on BDNF as a target for diabetic cognitive dysfunction.
PG  - 551-4
LID - 10.6026/97320630009551 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a known cause of cognitive dysfunction and 
      involves increased risk of dementia. Brain-derived neurotrophic factor (BDNF) is 
      a member of neurotrophic family of nerve growth factors, a key protein in 
      promoting memory, growth and survival of neurons. BDNF is recognized as a 
      metabotrophic factor, a molecule that is involved in Alzheimer's disease (AD) as 
      well as in other neurological disorders. It provides cellular and local 
      regulatory mechanisms for mediating synaptic plasticity. Impaired BDNF signaling 
      can compromise many aspects of brain functions. Studies investigating the 
      relationship between diabetes and BDNF in adults demonstrate that BDNF levels are 
      decreased in T2DM and are regulated in response to plasma levels of glucose. BDNF 
      could serve as biomarker in predicting the development of obesity and T2DM. 
      Thirty-two cavities were predicted to locate the active sites of BDNF for the 
      ligands to bind. The shape of the site was identified by extracting the cavity 
      volume surfaces enclosing regions with highest probability. Different ligands can 
      be chosen for interaction of active sites of BDNF and can be targeted for drug 
      discovery. This review focuses on computational exploitation selectively to 
      deliver BDNF as a drug to appropriate hypothalamic neurons, which can serve as a 
      novel approach in diabetic encephalopathy treatment.
FAU - Rao, Allam Appa
AU  - Rao AA
AD  - CR Rao Advanced Institute for Mathematics, Statistics & Computer Science 
      (AIMSCS), University of Hyderabad Campus, Gachibowli, Prof. CR Rao Road, 
      Hyderabad, Andhra Pradesh, India 500 046.
LA  - eng
PT  - Journal Article
DEP - 20130629
PL  - Singapore
TA  - Bioinformation
JT  - Bioinformation
JID - 101258255
PMC - PMC3717181
OTO - NOTNLM
OT  - BDNF
OT  - Brain derived neurotrophic factor
OT  - Diabetes
OT  - cognition
OT  - computational approach
EDAT- 2013/07/28 06:00
MHDA- 2013/07/28 06:01
PMCR- 2013/01/01
CRDT- 2013/07/27 06:00
PHST- 2013/06/05 00:00 [received]
PHST- 2013/06/17 00:00 [revised]
PHST- 2013/06/17 00:00 [accepted]
PHST- 2013/07/27 06:00 [entrez]
PHST- 2013/07/28 06:00 [pubmed]
PHST- 2013/07/28 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 97320630009551 [pii]
AID - 10.6026/97320630009551 [doi]
PST - epublish
SO  - Bioinformation. 2013 Jun 29;9(11):551-4. doi: 10.6026/97320630009551. Print 2013.