PMID- 23888240
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130726
LR  - 20211021
IS  - 2038-8322 (Print)
IS  - 2038-8330 (Electronic)
IS  - 2038-8322 (Linking)
VI  - 5
IP  - 1
DP  - 2013 Jan 25
TI  - Male-to-female sex ratios of abnormalities detected by fluorescence in situ 
      hybridization in a population of chronic lymphocytic leukemia patients.
PG  - 13-7
LID - 10.4081/hr.2013.e4 [doi]
AB  - Distorted sex ratios occur in hematologic disorders. For example, chronic 
      lymphocytic leukemia (CLL) displays disproportionate sex ratios with a large male 
      excess. However, the underlying genetics for these disparities are poorly 
      understood, and gender differences for specific cytogenetic abnormalities have 
      not been carefully investigated. We sought to provide an initial characterization 
      of gender representation in genetic abnormalities in CLL by using fluorescence in 
      situ hybridization (FISH). We confirm the well known skewed male-tofemale (M/F 
      sex ratio) of ~1.5 in our CLL study population, but also determine the genotypic 
      M/F sex ratio values corresponding to specific FISH DNA probes. Genetic changes 
      in CLL detectable by four FISH probes were statistically compared with respect to 
      gender. Initial FISH evaluations of 4698 CLL patients were retrospectively 
      examined and new findings of the genotypic M/F sex ratios for these probes are 
      reported. This study represents the largest CLL survey conducted in the United 
      States using FISH probes. The CLL database demonstrated that FISH abnormalities 
      (trisomy 12, 13q14.3 deletion and 17p13.1 deletion) probes had skewed M/F ratios 
      of ~1.5. Also, by statistical analysis it was shown that ATM gene loss 
      (11q22.3q23.1 deletion) solely or with other abnormalities was considerably 
      higher in males with an M/F ratio of 2.5 and significantly different from M/F 
      ratios of 1.0 or 1.5. We hypothesize that interactions involving these autosomal 
      abnormalities (trisomy 12, and deletions of 11q22.3, 13q14.3, and 17p13.1), and 
      the sex chromosomes may provide the genetic basis for the altered phenotypic M/F 
      ratio in CLL.
FAU - Cantu, Eduardo S
AU  - Cantu ES
AD  - Integrated Oncology, LabCorp Specialty Testing Group , Phoenix, AZ.
FAU - McGill, John R
AU  - McGill JR
FAU - Stephenson, Christine F
AU  - Stephenson CF
FAU - Hoffmann, Heidi M
AU  - Hoffmann HM
FAU - Tang, Lihua
AU  - Tang L
FAU - Yan, Jim
AU  - Yan J
FAU - Glassman, Armand B
AU  - Glassman AB
LA  - eng
PT  - Journal Article
DEP - 20130211
PL  - Switzerland
TA  - Hematol Rep
JT  - Hematology reports
JID - 101556723
PMC - PMC3719107
OTO - NOTNLM
OT  - CLL
OT  - FISH
OT  - sex ratios
EDAT- 2013/07/28 06:00
MHDA- 2013/07/28 06:01
PMCR- 2013/02/11
CRDT- 2013/07/27 06:00
PHST- 2012/10/27 00:00 [received]
PHST- 2013/01/16 00:00 [revised]
PHST- 2013/01/24 00:00 [accepted]
PHST- 2013/07/27 06:00 [entrez]
PHST- 2013/07/28 06:00 [pubmed]
PHST- 2013/07/28 06:01 [medline]
PHST- 2013/02/11 00:00 [pmc-release]
AID - 10.4081/hr.2013.e4 [doi]
PST - epublish
SO  - Hematol Rep. 2013 Feb 11;5(1):13-7. doi: 10.4081/hr.2013.e4. Print 2013 Jan 25.