PMID- 23888270
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20141118
LR  - 20220408
IS  - 2193-1801 (Print)
IS  - 2193-1801 (Electronic)
IS  - 2193-1801 (Linking)
VI  - 2
IP  - 1
DP  - 2013 Dec
TI  - Succinate dehydrogenase expression in breast cancer.
PG  - 299
LID - 10.1186/2193-1801-2-299 [doi]
LID - 299
AB  - The aim of this study was to investigate succinate dehydrogenase (SDH) expression 
      in breast cancer according to breast cancer molecular subtype using 
      immunohistochemistry and to assess the clinical implications of SDH expression. 
      Immunohistochemical staining for ER, PR, HER-2, Ki-67, HIF-1alpha, SDHA, and SDHB was 
      performed on tissue microarrays of 721 breast cancers. According to the 
      immunohistochemistry results for ER, PR, HER-2, and Ki-67 and fluorescence in 
      situ hybridization (FISH) results for HER-2, breast cancer molecular subtypes 
      were classified into luminal A, luminal B, HER-2, and triple-negative breast 
      cancer (TNBC). HER-2 subtype breast cancers most frequently showed high-level 
      expression of SDHA in tumor cells, while the luminal A subtype most frequently 
      showed low or negative expression of SDHA in tumor cells (P = 0.032). Stromal 
      SDHB expression rate was highest in HER-2 subtype and lowest in TNBC (P < 0.001). 
      SDHA-negative breast cancers were associated with younger age at diagnosis 
      (P = 0.012), and SDHB-negative breast cancers with lower histologic grade 
      (P = 0.044) and lower Ki-67 labeling index (LI) (P = 0.046). Tumor phenotypes 
      according to the SDH status were 
      SDHA(+)/SDHB(+) > SDHA(-)/SDHB(-) > SDHA(-)/SDHB(+) > SDHA(+)/SDHB(-) in order of 
      frequency. The stromal phenotypes were 
      SDHA(-)/SDHB(-) > SDHA(+)/SDHB(+) > SDHA(-)/SDHB(+) > SDHA(+)/SDHB(-). In 
      conclusion, loss of SDHA or SDHB expression was observed in about 3% of breast 
      cancers in this study. Low SDH expression status in breast tumor cells was 
      associated with younger age at diagnosis and low-grade histology.
FAU - Kim, Sewha
AU  - Kim S
AD  - Department of Pathology, Yonsei University College of Medicine, Seoul, South 
      Korea.
FAU - Kim, Do Hee
AU  - Kim DH
FAU - Jung, Woo-Hee
AU  - Jung WH
FAU - Koo, Ja Seung
AU  - Koo JS
LA  - eng
PT  - Journal Article
DEP - 20130703
PL  - Switzerland
TA  - Springerplus
JT  - SpringerPlus
JID - 101597967
PMC - PMC3710570
OTO - NOTNLM
OT  - Breast
OT  - Metabolism
OT  - Mitochondria
OT  - Succinate dehydrogenase
EDAT- 2013/07/28 06:00
MHDA- 2013/07/28 06:01
PMCR- 2013/07/03
CRDT- 2013/07/27 06:00
PHST- 2013/06/10 00:00 [received]
PHST- 2013/06/20 00:00 [accepted]
PHST- 2013/07/27 06:00 [entrez]
PHST- 2013/07/28 06:00 [pubmed]
PHST- 2013/07/28 06:01 [medline]
PHST- 2013/07/03 00:00 [pmc-release]
AID - 378 [pii]
AID - 10.1186/2193-1801-2-299 [doi]
PST - epublish
SO  - Springerplus. 2013 Jul 3;2(1):299. doi: 10.1186/2193-1801-2-299. Print 2013 Dec.