PMID- 23889837
OWN - NLM
STAT- MEDLINE
DCOM- 20140311
LR  - 20220310
IS  - 1460-6984 (Electronic)
IS  - 1368-2822 (Linking)
VI  - 48
IP  - 4
DP  - 2013 Jul-Aug
TI  - A randomized, rater-blinded, parallel trial of intensive speech therapy in 
      sub-acute post-stroke aphasia: the SP-I-R-IT study.
PG  - 421-31
LID - 10.1111/1460-6984.12018 [doi]
AB  - BACKGROUND: There is conflicting evidence regarding the benefits of intensive 
      speech and language therapy (SLT), particularly because intensity is often 
      confounded with total SLT provided. AIMS: A two-centre, randomized, 
      rater-blinded, parallel study was conducted to compare the efficacy of 100 h of 
      SLT in a regular (RT) versus intensive (IT) treatment in sub-acute post-stroke 
      aphasia. METHODS & PROCEDURES: Consecutive patients with aphasia, within 3 months 
      of a left hemisphere ischemic stroke, were randomized to IT (2 h per day x 5 days 
      per week, 10 weeks) or RT (2 h per week x 50 weeks). Evaluations took place at 
      10, 50 and 62 weeks. Primary outcome was the frequency of responders, defined by 
      15% increase of Aphasia Quotient (AQ) from the baseline to 50 weeks. Secondary 
      outcomes were changes from the baseline in AQ and functional communication 
      profile (FCP) at 50 and 62 weeks and improvement stability between 50 and 62 
      weeks. OUTCOMES & RESULTS: Thirty patients were randomized and 18 completed the 
      study. No significant differences were found between groups in primary or 
      secondary outcomes, although IT patients (N = 9) obtained higher scores in 
      language measures between 10 and 62 weeks in per protocol analysis. The number of 
      non-completions was identical between groups. CONCLUSIONS & IMPLICATIONS: This 
      study suggests that, in the sub-acute period following stroke and controlling for 
      the number of hours of SLT provided, there is a trend for a greater improvement 
      in language and functional communication measures with IT compared with RT. The 
      lack of statistical significance in results was probably due to the small sample 
      size.
CI  - (c) 2013 Royal College of Speech and Language Therapists.
FAU - Martins, Isabel Pavao
AU  - Martins IP
AD  - Language Research Laboratory, Department of Neurosciences, Lisbon Faculty of 
      Medicine, Instituto de Medicina Molecular, Hospital de Sta Maria, Lisbon, 
      Portugal. Isabel_Martins@fm.ul.pt
FAU - Leal, Gabriela
AU  - Leal G
FAU - Fonseca, Isabel
AU  - Fonseca I
FAU - Farrajota, Luisa
AU  - Farrajota L
FAU - Aguiar, Marta
AU  - Aguiar M
FAU - Fonseca, Jose
AU  - Fonseca J
FAU - Lauterbach, Martin
AU  - Lauterbach M
FAU - Goncalves, Luis
AU  - Goncalves L
FAU - Cary, M Carmo
AU  - Cary MC
FAU - Ferreira, Joaquim J
AU  - Ferreira JJ
FAU - Ferro, Jose M
AU  - Ferro JM
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20130416
PL  - United States
TA  - Int J Lang Commun Disord
JT  - International journal of language & communication disorders
JID - 9803709
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Aphasia/*rehabilitation
MH  - Brain Ischemia/rehabilitation
MH  - Communication
MH  - Communication Disorders/*rehabilitation
MH  - Female
MH  - Humans
MH  - Infarction, Middle Cerebral Artery/*rehabilitation
MH  - Male
MH  - Middle Aged
MH  - Single-Blind Method
MH  - Speech Therapy/*methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - aphasia
OT  - clinical trial
OT  - intensive speech therapy
OT  - speech and language therapy
OT  - stroke rehabilitation
EDAT- 2013/07/31 06:00
MHDA- 2014/03/13 06:00
CRDT- 2013/07/30 06:00
PHST- 2013/07/30 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - 10.1111/1460-6984.12018 [doi]
PST - ppublish
SO  - Int J Lang Commun Disord. 2013 Jul-Aug;48(4):421-31. doi: 
      10.1111/1460-6984.12018. Epub 2013 Apr 16.