PMID- 23890415
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20211021
IS  - 1096-0961 (Electronic)
IS  - 1079-9796 (Print)
IS  - 1079-9796 (Linking)
VI  - 52
IP  - 1
DP  - 2014 Jan
TI  - TNF-alpha signaling in Fanconi anemia.
PG  - 2-11
LID - S1079-9796(13)00151-4 [pii]
LID - 10.1016/j.bcmd.2013.06.005 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a major pro-inflammatory cytokine involved 
      in systemic inflammation and the acute phase reaction. Dysregulation of TNF 
      production has been implicated in a variety of human diseases including Fanconi 
      anemia (FA). FA is a genomic instability syndrome characterized by progressive 
      bone marrow failure and cancer susceptibility. The patients with FA are often 
      found overproducing TNF-alpha, which may directly affect hematopoietic stem cell 
      (HSC) function by impairing HSC survival, homing and proliferation, or indirectly 
      change the bone marrow microenvironment critical for HSC homeostasis and 
      function, therefore contributing to disease progression in FA. In this brief 
      review, we discuss the link between TNF-alpha signaling and FA pathway with emphasis 
      on the implication of inflammation in the pathophysiology and abnormal 
      hematopoiesis in FA.
CI  - (c) 2013.
FAU - Du, Wei
AU  - Du W
AD  - Division of Experimental Hematology and Cancer Biology, University of Cincinnati 
      College of Medicine, Cincinnati, OH 45229, USA. Electronic address: 
      wei.du@cchmc.org.
FAU - Erden, Ozlem
AU  - Erden O
FAU - Pang, Qishen
AU  - Pang Q
LA  - eng
GR  - P30 DK090971/DK/NIDDK NIH HHS/United States
GR  - R01 CA157537/CA/NCI NIH HHS/United States
GR  - R01 HL076712/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130724
PL  - United States
TA  - Blood Cells Mol Dis
JT  - Blood cells, molecules & diseases
JID - 9509932
RN  - 0 (Fanconi Anemia Complementation Group Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Apoptosis
MH  - Bone Marrow/immunology/*pathology
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Cell Transformation, Neoplastic/immunology/pathology
MH  - Fanconi Anemia/*genetics/immunology/pathology
MH  - Fanconi Anemia Complementation Group Proteins/*genetics/immunology
MH  - Gene Expression Regulation
MH  - Genomic Instability
MH  - Hematopoietic Stem Cells/immunology/*pathology
MH  - Humans
MH  - Inflammation/genetics/immunology/pathology
MH  - Signal Transduction/*genetics/immunology
MH  - Tumor Necrosis Factor-alpha/*genetics/immunology
PMC - PMC3851925
MID - NIHMS509990
OTO - NOTNLM
OT  - DNA repair
OT  - Fanconi anemia
OT  - Hematopoietic failure inflammation
OT  - Leukemia
OT  - TNF-alpha
EDAT- 2013/07/31 06:00
MHDA- 2014/07/16 06:00
PMCR- 2015/01/01
CRDT- 2013/07/30 06:00
PHST- 2013/06/18 00:00 [received]
PHST- 2013/06/20 00:00 [revised]
PHST- 2013/06/20 00:00 [accepted]
PHST- 2013/07/30 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - S1079-9796(13)00151-4 [pii]
AID - 10.1016/j.bcmd.2013.06.005 [doi]
PST - ppublish
SO  - Blood Cells Mol Dis. 2014 Jan;52(1):2-11. doi: 10.1016/j.bcmd.2013.06.005. Epub 
      2013 Jul 24.