PMID- 23890452
OWN - NLM
STAT- MEDLINE
DCOM- 20131022
LR  - 20211021
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 14
DP  - 2013 Jul 26
TI  - Single nucleotide polymorphisms associated with non-contact soft tissue injuries 
      in elite professional soccer players: influence on degree of injury and recovery 
      time.
PG  - 221
LID - 10.1186/1471-2474-14-221 [doi]
AB  - BACKGROUND: The biological mechanisms involved in non-contact musculoskeletal 
      soft tissue injuries (NCMSTI) are poorly understood. Genetic risk factors may be 
      associated with susceptibility to injuries, and may exert marked influence on 
      recovery times. METHODS: Data on type and degree of injury and recovery time were 
      collected in 73 male professional soccer players (43 White, 11 Black Africans and 
      19 Hispanics) who suffered total of 242 injuries (203 muscle, 24 ligament, and 15 
      tendon injuries). One single nucleotide polymorphism (SNPs) in the following 
      genes were analyzed: Elastin (ELN); Titin (TTN); SRY-related HMG-box (SOX15); 
      Insulin-like growth factor 2 (IGF2); Chemokine, CC motif, ligand 2 (CCL2); 
      Collagen type 1 alpha 1(COL1A1); Collagen type 5 alpha 1 (COL5A1), and Tenascin C 
      (TNC). RESULTS: There was evidence of a statistically significant association 
      between the degree of injury and the IGF2 genotype (P = 0.034). In addition, 
      there was evidence of a statistically significant association between the degree 
      of muscle injury and CCL2 (P = 0.026) Finally, there was evidence of a 
      statistically significant association between ELN and degree of injury 
      (p = 0.009) and recovery time (P = 0.043). There was no evidence of a 
      statistically significant association between any of the genes studied and degree 
      of injury or recovery time for tendon injuries. CONCLUSION: SNPs in the IGF2, 
      CCL2, and ELN genes may be associated to the degree and recovery time of NCMSTI.
FAU - Pruna, Ricard
AU  - Pruna R
AD  - FC Barcelona Medical Services, Barcelona, Spain.
FAU - Artells, Rosa
AU  - Artells R
FAU - Ribas, Jordi
AU  - Ribas J
FAU - Montoro, Bruno
AU  - Montoro B
FAU - Cos, Francesc
AU  - Cos F
FAU - Munoz, Carme
AU  - Munoz C
FAU - Rodas, Gil
AU  - Rodas G
FAU - Maffulli, Nicola
AU  - Maffulli N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130726
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IGF2 protein, human)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
RN  - 9007-58-3 (Elastin)
SB  - IM
MH  - Adult
MH  - Athletic Injuries/*genetics/pathology/physiopathology
MH  - Chemokine CCL2/genetics
MH  - Elastin/genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Insulin-Like Growth Factor II/genetics
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Recovery of Function
MH  - *Soccer
MH  - Soft Tissue Injuries/*genetics/pathology/physiopathology
MH  - Time Factors
MH  - Trauma Severity Indices
MH  - Young Adult
PMC - PMC3726514
EDAT- 2013/07/31 06:00
MHDA- 2013/10/23 06:00
PMCR- 2013/07/26
CRDT- 2013/07/30 06:00
PHST- 2013/06/12 00:00 [received]
PHST- 2013/07/03 00:00 [accepted]
PHST- 2013/07/30 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2013/10/23 06:00 [medline]
PHST- 2013/07/26 00:00 [pmc-release]
AID - 1471-2474-14-221 [pii]
AID - 10.1186/1471-2474-14-221 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2013 Jul 26;14:221. doi: 10.1186/1471-2474-14-221.