PMID- 23890582
OWN - NLM
STAT- MEDLINE
DCOM- 20140513
LR  - 20201206
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 151
IP  - 2
DP  - 2013 Nov
TI  - Investigating the role of BDNF and CCK system genes in suicidality in a familial 
      bipolar cohort.
PG  - 611-617
LID - S0165-0327(13)00559-4 [pii]
LID - 10.1016/j.jad.2013.07.006 [doi]
AB  - BACKGROUND: Suicidal behaviour is a phenotype widely associated with psychiatric 
      disorders such as major depressive disorder and bipolar disorder. However, recent 
      evidence indicates that part of the heritability of suicidal behaviour is 
      independent of the heritability of individual psychiatric disorders. This allows 
      investigation into genetic risk factors for suicidal behaviour within a disorder 
      using a candidate gene association approach. METHODS: We used family-based 
      association testing in a cohort of 130 multiplex bipolar pedigrees, comprising 
      795 individuals, to look for associations between suicidal behaviour and 32 
      single nucleotide polymorphisms (SNPs) from across the genes brain-derived 
      neurotrophic factor (BDNF), cholecystokinin (CCK) and the cholecystokinin 
      beta-receptor (CCKBR). RESULTS: We found associations (p</=0.05) between suicide 
      attempt and 12 SNPs of CCKBR and five SNPs of BDNF. After correction for multiple 
      testing, seven SNPs of CCKBR remained significantly associated. No association 
      was found between CCK and suicidal behaviour. LIMITATIONS: The study relied on 
      retrospective self-reporting by individuals to determine phenotype, and the 
      sample size was relatively small. CONCLUSIONS: The results of the study support 
      the hypothesis that some CCKBR polymorphisms may contribute to an underlying 
      predisposition towards suicidal behaviour in bipolar disorder.
CI  - (c) 2013 Elsevier B.V. All rights reserved.
FAU - Sears, Catherine
AU  - Sears C
AD  - Department of Pathology, Dunedin School of Medicine, University of Otago, P.O. 
      Box 913, Dunedin 9054, New Zealand.
FAU - Wilson, Julia
AU  - Wilson J
AD  - Department of Pathology, Dunedin School of Medicine, University of Otago, P.O. 
      Box 913, Dunedin 9054, New Zealand.
FAU - Fitches, Alison
AU  - Fitches A
AD  - Department of Pathology, Dunedin School of Medicine, University of Otago, P.O. 
      Box 913, Dunedin 9054, New Zealand. Electronic address: 
      alison.fitches@otago.ac.nz.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130723
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptor, Cholecystokinin B)
RN  - 9011-97-6 (Cholecystokinin)
SB  - IM
MH  - Bipolar Disorder/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cholecystokinin/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Receptor, Cholecystokinin B/*genetics
MH  - Retrospective Studies
MH  - *Suicide
OTO - NOTNLM
OT  - Association study
OT  - BDNF
OT  - Bipolar disorder
OT  - CCK
OT  - CCKBR
OT  - Suicide
EDAT- 2013/07/31 06:00
MHDA- 2014/05/14 06:00
CRDT- 2013/07/30 06:00
PHST- 2013/02/19 00:00 [received]
PHST- 2013/07/04 00:00 [revised]
PHST- 2013/07/04 00:00 [accepted]
PHST- 2013/07/30 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2014/05/14 06:00 [medline]
AID - S0165-0327(13)00559-4 [pii]
AID - 10.1016/j.jad.2013.07.006 [doi]
PST - ppublish
SO  - J Affect Disord. 2013 Nov;151(2):611-617. doi: 10.1016/j.jad.2013.07.006. Epub 
      2013 Jul 23.