PMID- 23890813
OWN - NLM
STAT- MEDLINE
DCOM- 20131106
LR  - 20200623
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 444
IP  - 1-2
DP  - 2013 Sep
TI  - Rotavirus NSP1 inhibits interferon induced non-canonical NFkappaB activation by 
      interacting with TNF receptor associated factor 2.
PG  - 41-4
LID - S0042-6822(13)00405-4 [pii]
LID - 10.1016/j.virol.2013.07.003 [doi]
AB  - TNF receptor associated factor 2 (TRAF2) plays a very important role in cellular 
      innate immune as well as inflammatory responses. Previous studies have reported 
      TRAF2 mediated regulation of TNF and Interferon (IFN) induced canonical and 
      non-canonical activation of NFkappaB. In this study, we show that rotavirus NSP1 
      targets TRAF2 to regulate IFN induced non-canonical NFkappaB activation. Here we 
      found that rotavirus Non-Structural Protein-1 (NSP1) interacts with TRAF2 and 
      degrades it in a proteasome dependent manner. C-terminal part of NSP1 was 
      sufficient for interacting with TRAF2 but it alone could not degrade TRAF2. This 
      inhibition of interferon mediated non-canonical NFkappaB activation by NSP1 may 
      modulate inflammatory cytokine production after rotavirus infection to help the 
      virus propagation.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Bagchi, Parikshit
AU  - Bagchi P
AD  - Division of Virology, National Institute of Cholera and Enteric Diseases, P-33, 
      C.I.T. Road Scheme-XM, Beliaghata, Kolkata 700010, West Bengal, India.
FAU - Bhowmick, Rahul
AU  - Bhowmick R
FAU - Nandi, Satabdi
AU  - Nandi S
FAU - Kant Nayak, Mukti
AU  - Kant Nayak M
FAU - Chawla-Sarkar, Mamta
AU  - Chawla-Sarkar M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130723
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (NF-kappa B)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 0 (Viral Nonstructural Proteins)
RN  - 0 (nsp1 protein, Rotavirus)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - Interferons/*immunology
MH  - NF-kappa B/*antagonists & inhibitors
MH  - Protein Interaction Mapping
MH  - Proteolysis
MH  - Rotavirus/*immunology
MH  - TNF Receptor-Associated Factor 2/*antagonists & inhibitors/metabolism
MH  - Viral Nonstructural Proteins/*metabolism
OTO - NOTNLM
OT  - NFkappaB
OT  - NSP1
OT  - Rotavirus
OT  - TRAF2
EDAT- 2013/07/31 06:00
MHDA- 2013/11/07 06:00
CRDT- 2013/07/30 06:00
PHST- 2013/05/03 00:00 [received]
PHST- 2013/05/25 00:00 [revised]
PHST- 2013/07/03 00:00 [accepted]
PHST- 2013/07/30 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2013/11/07 06:00 [medline]
AID - S0042-6822(13)00405-4 [pii]
AID - 10.1016/j.virol.2013.07.003 [doi]
PST - ppublish
SO  - Virology. 2013 Sep;444(1-2):41-4. doi: 10.1016/j.virol.2013.07.003. Epub 2013 Jul 
      23.