PMID- 23891757
OWN - NLM
STAT- MEDLINE
DCOM- 20140715
LR  - 20131021
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 110
DP  - 2013 Sep
TI  - Anti-aggressive effect elicited by coca-paste in isolation-induced aggression of 
      male rats: influence of accumbal dopamine and cortical serotonin.
PG  - 216-23
LID - S0091-3057(13)00178-0 [pii]
LID - 10.1016/j.pbb.2013.07.010 [doi]
AB  - Coca-paste (CP), an illicit drug of abuse, has been frequently associated with 
      aggressive and impulsive behaviors in humans. However, preclinical studies have 
      not been carried out in order to characterize CP effects on aggression. The acute 
      effect of CP, cocaine and caffeine (the main adulterant present in seized 
      samples) on aggression was assessed using the isolation-induced aggression 
      paradigm in male rats. The dopaminergic (DA) neurotransmission in the nucleus 
      accumbens (NAcc) and serotonergic (5-HT) activity in the frontal cortex were 
      explored. CP and cocaine induced a similar anti-aggressive effect on isolated 
      rats although CP-treated animals showed a shorter latency to the first attack. 
      Aggressive behavior was not increased per se by caffeine. Social investigation 
      time was slightly reduced only by cocaine while exploratory activity and time 
      spent walking were increased by the three drugs. Accumbal DA levels were 
      significantly augmented by CP, cocaine and caffeine, although differences in 
      DOPAC and HVA levels were evidenced. A decrease in DA turnover was only observed 
      after CP and cocaine administration. Increased cortical 5-HT levels with a 
      concomitant decrease in 5-HT turnover were observed after CP and cocaine whereas 
      caffeine did not alter it. As cocaine but not caffeine reduced aggression, it 
      seems like cocaine content was mainly responsible for CP anti-aggressive action; 
      however, the presence of caffeine in CP may have a role in the shorter latency to 
      attack compared to cocaine. Despite the increase in NAcc DA, the enhancement of 
      cortical 5-HT levels can likely underlie the anti-aggression observed in 
      CP-treated animals.
CI  - (c) 2013 Elsevier Inc. All rights reserved.
FAU - Meikle, Maria Noel
AU  - Meikle MN
AD  - Laboratorio de Biologia Celular, Instituto de Investigaciones Biologicas Clemente 
      Estable (IIBCE), Uruguay.
FAU - Prieto, Jose Pedro
AU  - Prieto JP
FAU - Urbanavicius, Jessika
AU  - Urbanavicius J
FAU - Lopez, Ximena
AU  - Lopez X
FAU - Abin-Carriquiry, Juan Andres
AU  - Abin-Carriquiry JA
FAU - Prunell, Giselle
AU  - Prunell G
FAU - Scorza, Maria Cecilia
AU  - Scorza MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130724
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 333DO1RDJY (Serotonin)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Aggression/*drug effects
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Cerebral Cortex/drug effects/metabolism
MH  - *Coca
MH  - Dopamine/*metabolism
MH  - Male
MH  - Nucleus Accumbens/drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/*metabolism
MH  - *Social Isolation
OTO - NOTNLM
OT  - Aggression
OT  - Caffeine
OT  - Coca-paste
OT  - Cocaine
OT  - Dopamine
OT  - Serotonin
EDAT- 2013/07/31 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/07/30 06:00
PHST- 2013/02/16 00:00 [received]
PHST- 2013/07/09 00:00 [revised]
PHST- 2013/07/13 00:00 [accepted]
PHST- 2013/07/30 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - S0091-3057(13)00178-0 [pii]
AID - 10.1016/j.pbb.2013.07.010 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2013 Sep;110:216-23. doi: 10.1016/j.pbb.2013.07.010. 
      Epub 2013 Jul 24.