PMID- 23892128
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20181202
IS  - 1879-0984 (Electronic)
IS  - 0166-0934 (Linking)
VI  - 193
IP  - 2
DP  - 2013 Nov
TI  - Minimal sequence variability of the region of HIV-1 integrase targeted by the 
      Abbott RealTime HIV-1 viral load assay in clinical specimens with reduced 
      susceptibility to raltegravir.
PG  - 693-6
LID - S0166-0934(13)00282-6 [pii]
LID - 10.1016/j.jviromet.2013.07.028 [doi]
AB  - The Abbott RealTime (ART) HIV-1 assay targets the integrase region and is 
      designed to tolerate mismatches. Variability in integrase sequences comprising 
      the assay target regions from >1000 clinical specimens submitted for phenotypic 
      and genotypic raltegravir resistance testing were analyzed. In this large 
      collection of sequences from clinical specimens, the number and location of 
      raltegravir resistance associated mutations did not differ from those tested 
      previously and shown not to result in under-estimation of viral loads.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Young, Thomas P
AU  - Young TP
AD  - Abbott Molecular, Des Plaines, IL USA; University of California San Francisco, 
      Department of Community Health, San Francisco, CA, USA. Electronic address: 
      thomas.young@ucsf.edu.
FAU - Napolitano, Laura A
AU  - Napolitano LA
FAU - Paquet, Agnes C
AU  - Paquet AC
FAU - Parkin, Neil T
AU  - Parkin NT
FAU - Fransen, Signe
AU  - Fransen S
FAU - Trinh, Roger
AU  - Trinh R
FAU - Haddad, Mojgan
AU  - Haddad M
FAU - Hackett, John Jr
AU  - Hackett J Jr
FAU - Cloherty, Gavin A
AU  - Cloherty GA
LA  - eng
PT  - Journal Article
DEP - 20130725
PL  - Netherlands
TA  - J Virol Methods
JT  - Journal of virological methods
JID - 8005839
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Pyrrolidinones)
RN  - 43Y000U234 (Raltegravir Potassium)
RN  - EC 2.7.7.- (HIV Integrase)
RN  - YY6481J2FF (p31 integrase protein, Human immunodeficiency virus 1)
SB  - IM
MH  - Anti-HIV Agents/*pharmacology
MH  - *Drug Resistance, Viral
MH  - Genetic Variation
MH  - HIV Infections/*virology
MH  - HIV Integrase/*genetics
MH  - HIV-1/drug effects/*genetics/isolation & purification
MH  - Mutation
MH  - Pyrrolidinones/*pharmacology
MH  - Raltegravir Potassium
MH  - Viral Load/*methods
OTO - NOTNLM
OT  - Assay
OT  - HIV
OT  - Integrase inhibitor resistance
OT  - Sequence variability
EDAT- 2013/07/31 06:00
MHDA- 2014/04/20 06:00
CRDT- 2013/07/30 06:00
PHST- 2012/10/30 00:00 [received]
PHST- 2013/07/07 00:00 [revised]
PHST- 2013/07/12 00:00 [accepted]
PHST- 2013/07/30 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
AID - S0166-0934(13)00282-6 [pii]
AID - 10.1016/j.jviromet.2013.07.028 [doi]
PST - ppublish
SO  - J Virol Methods. 2013 Nov;193(2):693-6. doi: 10.1016/j.jviromet.2013.07.028. Epub 
      2013 Jul 25.