PMID- 23892199
OWN - NLM
STAT- MEDLINE
DCOM- 20140415
LR  - 20220408
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 97
IP  - 1
DP  - 2014 Feb 27
TI  - Neurotoxicity of methamphetamine and 3,4-methylenedioxymethamphetamine.
PG  - 37-44
LID - S0024-3205(13)00401-3 [pii]
LID - 10.1016/j.lfs.2013.07.014 [doi]
AB  - Amphetamines are a class of psychostimulant drugs that are widely abused for 
      their stimulant, euphoric, empathogenic and hallucinogenic properties. Many of 
      these effects result from acute increases in dopamine and serotonin 
      neurotransmission. Subsequent to these acute effects, methamphetamine and 3,4 
      methylenedioxymethamphetamine (MDMA) produce persistent damage to dopamine and 
      serotonin nerve terminals. This review summarizes the numerous interdependent 
      mechanisms including excitotoxicity, mitochondrial damage and oxidative stress 
      that have been demonstrated to contribute to this damage. Emerging non-neuronal 
      mechanisms by which the drugs may contribute to monoaminergic terminal damage, as 
      well as the neuropsychiatric consequences of this terminal damage are also 
      presented. Methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) have 
      similar chemical structures and pharmacologic properties compared to other abused 
      substances including cathinone (khat), as well as a relatively new class of novel 
      synthetic amphetamines known as 'bath salts' that have gained popularity among 
      drug abusers.
CI  - (c) 2013.
FAU - Halpin, Laura E
AU  - Halpin LE
AD  - Department of Neurosciences, University of Toledo College of Medicine, 3000 
      Arlington Ave., Toledo, OH 43614, USA.
FAU - Collins, Stuart A
AU  - Collins SA
AD  - Department of Neurosciences, University of Toledo College of Medicine, 3000 
      Arlington Ave., Toledo, OH 43614, USA.
FAU - Yamamoto, Bryan K
AU  - Yamamoto BK
AD  - Department of Neurosciences, University of Toledo College of Medicine, 3000 
      Arlington Ave., Toledo, OH 43614, USA. Electronic address: 
      Bryan.Yamamoto@utoledo.edu.
LA  - eng
GR  - R01 DA007606/DA/NIDA NIH HHS/United States
GR  - R01 DA035499/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20130724
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - 333DO1RDJY (Serotonin)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Central Nervous System Stimulants/toxicity
MH  - Dopamine/metabolism
MH  - Hallucinogens/toxicity
MH  - Humans
MH  - Methamphetamine/*toxicity
MH  - Mitochondria/drug effects/pathology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Nerve Endings/drug effects/pathology
MH  - Neurotoxicity Syndromes/*etiology/physiopathology
MH  - Oxidative Stress/drug effects
MH  - Serotonin/metabolism
PMC - PMC3870191
MID - NIHMS509181
OTO - NOTNLM
OT  - 3-4-Methylenedioxymethamphetamine
OT  - Excitotoxicity
OT  - Methamphetamine
OT  - Neurotoxicity
OT  - Oxidative stress
OT  - Psychosis
COIS- Conflicts of Interest: All authors declare no conflicts of interest
EDAT- 2013/07/31 06:00
MHDA- 2014/04/16 06:00
PMCR- 2015/02/27
CRDT- 2013/07/30 06:00
PHST- 2013/05/17 00:00 [received]
PHST- 2013/07/05 00:00 [revised]
PHST- 2013/07/11 00:00 [accepted]
PHST- 2013/07/30 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2014/04/16 06:00 [medline]
PHST- 2015/02/27 00:00 [pmc-release]
AID - S0024-3205(13)00401-3 [pii]
AID - 10.1016/j.lfs.2013.07.014 [doi]
PST - ppublish
SO  - Life Sci. 2014 Feb 27;97(1):37-44. doi: 10.1016/j.lfs.2013.07.014. Epub 2013 Jul 
      24.