PMID- 23892330
OWN - NLM
STAT- MEDLINE
DCOM- 20140812
LR  - 20131204
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 48
IP  - 12
DP  - 2013 Nov
TI  - Towards a global system of vigilance and surveillance in unrelated donors of 
      haematopoietic progenitor cells for transplantation.
PG  - 1506-9
LID - 10.1038/bmt.2013.104 [doi]
AB  - Safety of living donors is critical to the success of blood, tissue and organ 
      transplantation. Structured and robust vigilance and surveillance systems exist 
      as part of some national entities, but historically no global systems are in 
      place to ensure conformity, harmonisation and the recognition of rare adverse 
      events (AEs). The World Health Assembly has recently resolved to require 
      AE/reaction (AE/R) reporting both nationally and globally. The World Marrow Donor 
      Association (WMDA) is an international organisation promoting the safety of 
      unrelated donors and progenitor cell products for use in haematopoietic 
      progenitor cell (HPC) transplantation. To address this issue, we established a 
      system for collecting, collating, analysing, distributing and reacting to serious 
      adverse events and reactions (SAE/R) in unrelated HPC donors. The WMDA 
      successfully instituted this reporting system with 203 SAE/R reported in 2011. 
      The committee generated two rapid reports, reacting to specific SAE/R, resulting 
      in practice changing policies. The system has a robust governance structure, 
      formal feedback to the WMDA membership and transparent information flows to other 
      agencies, specialist physicians and transplant programs and the general public.
FAU - Shaw, B E
AU  - Shaw BE
AD  - 1] Anthony Nolan Research Institute, Royal Free Hospital, UCL Cancer Centre, 
      London, UK [2] Royal Marsden NHS Foundation Trust, London, UK.
FAU - Chapman, J
AU  - Chapman J
FAU - Fechter, M
AU  - Fechter M
FAU - Foeken, L
AU  - Foeken L
FAU - Greinix, H
AU  - Greinix H
FAU - Hwang, W
AU  - Hwang W
FAU - Phillips-Johnson, L
AU  - Phillips-Johnson L
FAU - Korhonen, M
AU  - Korhonen M
FAU - Lindberg, B
AU  - Lindberg B
FAU - Navarro, W H
AU  - Navarro WH
FAU - Szer, J
AU  - Szer J
LA  - eng
PT  - Journal Article
DEP - 20130729
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Hematopoietic Stem Cells/*cytology
MH  - Humans
MH  - Registries
MH  - Tissue and Organ Procurement/*methods/*standards
MH  - Transplantation Conditioning/methods
MH  - *Unrelated Donors
EDAT- 2013/07/31 06:00
MHDA- 2014/08/13 06:00
CRDT- 2013/07/30 06:00
PHST- 2013/03/14 00:00 [received]
PHST- 2013/06/14 00:00 [revised]
PHST- 2013/06/17 00:00 [accepted]
PHST- 2013/07/30 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2014/08/13 06:00 [medline]
AID - bmt2013104 [pii]
AID - 10.1038/bmt.2013.104 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2013 Nov;48(12):1506-9. doi: 10.1038/bmt.2013.104. Epub 
      2013 Jul 29.