PMID- 23892719
OWN - NLM
STAT- MEDLINE
DCOM- 20140430
LR  - 20211021
IS  - 1476-5551 (Electronic)
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 28
IP  - 3
DP  - 2014 Mar
TI  - Deletion of the 1p32 region is a major independent prognostic factor in young 
      patients with myeloma: the IFM experience on 1195 patients.
PG  - 675-9
LID - 10.1038/leu.2013.225 [doi]
AB  - Deletions of the 1p region appear as a pejorative prognostic factor in multiple 
      myeloma patients (especially 1p22 and 1p32 deletions) but there is a lack of data 
      on the real impact of 1p abnormalities on an important and homogeneous group of 
      patients. To address this issue we studied by fluorescence in situ hybridization 
      (FISH) the incidence and prognostic impact of 1p22 and 1p32 deletions in 1195 
      patients from the IFM (Institut Francophone du Myelome) cell collection. 
      Chromosome 1p deletions were present in 23.3% of the patients (271): 15.1% (176) 
      for 1p22 and 7.3% (85) for 1p32 regions. In univariate analyses, 1p22 and 1p32 
      appeared as negative prognostic factors for progression-free survival (PFS): 
      1p22: 19.8 months vs 33.6 months (P<0.001) and 1p32: 14.4 months vs 33.6 months 
      (P<0.001); and overall survival (OS): 1p22: 44.2 months vs 96.8 months (P=0.002) 
      and 1p32: 26.7 months vs 96.8 months (P<0.001). In multivariate analyses, 1p22 
      and 1p32 deletions still appear as independent negative prognostic factors for 
      PFS and OS. In conclusion, our data show that 1p22 and 1p32 deletions are major 
      negative prognostic factors for PFS and OS for patients with MM. We thus suggest 
      that 1p32 deletion should be tested for all patients at diagnosis.
FAU - Hebraud, B
AU  - Hebraud B
AD  - Unite de Genomique du Myelome, University Hospital, CRCT, INSERM U 1037, 
      Universite Paul Sabatier, Toulouse, France.
FAU - Leleu, X
AU  - Leleu X
AD  - Service des Maladies du Sang, Hopital Claude Huriez, CHRU, Lille, France.
FAU - Lauwers-Cances, V
AU  - Lauwers-Cances V
AD  - Service d'Epidemiologie, CHU Toulouse, Toulouse, France.
FAU - Roussel, M
AU  - Roussel M
AD  - Hematologie Clinique, Hopital Purpan, Toulouse, France.
FAU - Caillot, D
AU  - Caillot D
AD  - Department of Hematology, University Hospital, Dijon, France.
FAU - Marit, G
AU  - Marit G
AD  - Department of Hematology, University Hospital, Bordeaux, France.
FAU - Karlin, L
AU  - Karlin L
AD  - Department of Hematology, University Hospital, Lyon, France.
FAU - Hulin, C
AU  - Hulin C
AD  - Department of Hematology, University Hospital, Nancy, France.
FAU - Gentil, C
AU  - Gentil C
AD  - Service d'Epidemiologie, CHU Toulouse, Toulouse, France.
FAU - Guilhot, F
AU  - Guilhot F
AD  - CIC Inserm 0802, Centre Hospitalier Universitaire, Poitiers, France.
FAU - Garderet, L
AU  - Garderet L
AD  - Department of Hematology, University Hospital, Paris, France.
FAU - Lamy, T
AU  - Lamy T
AD  - Department of Hematology, University Hospital, Rennes, France.
FAU - Brechignac, S
AU  - Brechignac S
AD  - Department of Hematology, University Hospital, Bobigny, France.
FAU - Pegourie, B
AU  - Pegourie B
AD  - Department of Hematology, University Hospital, Grenoble, France.
FAU - Jaubert, J
AU  - Jaubert J
AD  - Department of Hematology, University Hospital, St-Etienne, France.
FAU - Dib, M
AU  - Dib M
AD  - Department of Hematology, University Hospital, Angers, France.
FAU - Stoppa, A-M
AU  - Stoppa AM
AD  - Department of Hematology, Institut Paoli Calmette, Marseille, France.
FAU - Sebban, C
AU  - Sebban C
AD  - Department of Hematology, Centre Leon Berard, Lyon, France.
FAU - Fohrer, C
AU  - Fohrer C
AD  - Department of Hematology, University Hospital, Strasbourg, France.
FAU - Fontan, J
AU  - Fontan J
AD  - Department of Hematology, University Hospital, Besancon, France.
FAU - Fruchart, C
AU  - Fruchart C
AD  - Department of Hematology, Centre Francois Baclesse, Caen, France.
FAU - Macro, M
AU  - Macro M
AD  - Department of Hematology, University Hospital, Caen, France.
FAU - Orsini-Piocelle, F
AU  - Orsini-Piocelle F
AD  - Department of Hematology, Departmental Hospital, Annecy, France.
FAU - Lepeu, G
AU  - Lepeu G
AD  - Department of Hematology, Departmental Hospital, Avignon, France.
FAU - Sohn, C
AU  - Sohn C
AD  - Department of Hematology, Departmental Hospital, Toulon, France.
FAU - Corre, J
AU  - Corre J
AD  - Unite de Genomique du Myelome, University Hospital, CRCT, INSERM U 1037, 
      Universite Paul Sabatier, Toulouse, France.
FAU - Facon, T
AU  - Facon T
AD  - Service des Maladies du Sang, Hopital Claude Huriez, CHRU, Lille, France.
FAU - Moreau, P
AU  - Moreau P
AD  - Department of Hematology, University Hospital, Nantes, France.
FAU - Attal, M
AU  - Attal M
AD  - Hematologie Clinique, Hopital Purpan, Toulouse, France.
FAU - Avet-Loiseau, H
AU  - Avet-Loiseau H
AD  - Unite de Genomique du Myelome, University Hospital, CRCT, INSERM U 1037, 
      Universite Paul Sabatier, Toulouse, France.
LA  - eng
GR  - P01 CA155258/CA/NCI NIH HHS/United States
GR  - P01-155258/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130729
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 1
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Multiple Myeloma/*genetics/pathology
MH  - Prognosis
PMC - PMC6140327
MID - NIHMS987579
COIS- We have no conflict of interest to disclose.
EDAT- 2013/07/31 06:00
MHDA- 2014/05/03 06:00
PMCR- 2018/09/17
CRDT- 2013/07/30 06:00
PHST- 2013/02/22 00:00 [received]
PHST- 2013/07/03 00:00 [revised]
PHST- 2013/07/09 00:00 [accepted]
PHST- 2013/07/30 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
PHST- 2018/09/17 00:00 [pmc-release]
AID - leu2013225 [pii]
AID - 10.1038/leu.2013.225 [doi]
PST - ppublish
SO  - Leukemia. 2014 Mar;28(3):675-9. doi: 10.1038/leu.2013.225. Epub 2013 Jul 29.