PMID- 23896210
OWN - NLM
STAT- MEDLINE
DCOM- 20140701
LR  - 20131008
IS  - 1773-0597 (Electronic)
IS  - 0181-5512 (Linking)
VI  - 36
IP  - 8
DP  - 2013 Oct
TI  - [Macular choroidal thickness assessment with SD-OCT in high myopia with or 
      without choroidal neovascularization].
PG  - 687-92
LID - S0181-5512(13)00220-9 [pii]
LID - 10.1016/j.jfo.2013.03.009 [doi]
AB  - PURPOSE: To measure macular choroidal thickness (CT) using spectral-domain 
      optical coherence tomography (SD-OCT) in eyes with myopic macular choroidal 
      neovascularization (CNV), and to compare choroidal thickness in these eyes with 
      highly myopic eyes without CNV. PATIENTS AND METHODS: Sixty-four eyes with myopic 
      CNV matched with 64 highly myopic eyes without CNV by age and axial length (AL) 
      were examined between January 2010 and November 2011. OCT scans were performed 
      with spectral-domain OCT (TOPCON OCT 2000). The reference position was changed 
      from the vitreous to the choroid. OCT scan patterns consisted of seven sections; 
      the subfoveal CT was measured manually between Bruch's membrane and the internal 
      portion of the sclera in eyes with CNV and from the pigment epithelium to the 
      scleral interface in eyes without CNV. RESULTS: In the subgroup with CNV, the 
      mean subfoveal CT was 51.71 mum +/- 17.35. A statistically significant negative 
      correlation was found between CT and AL (r=-0.615, P=0.0001). Regression analysis 
      demonstrated a decrease of 8.4 mum per mm of AL. In the subgroup without CNV, 
      matched with the CNV subgroup by age (P=0.597), and AL (P=0.813), the mean 
      subfoveal CT was 93.35 mum +/- 34.81 mum. The difference between the two subgroups 
      was statistically significant (P<10(-4)). DISCUSSION: Macular choroidal thickness 
      is reduced in high myopia, especially when complicated by CNV. It has not yet 
      been shown that choroidal thinning may be a risk factor for choroidal 
      neovascularization, but our results may suggest that macular choroidal thinning 
      may lead to hypoxic retinal changes resulting in secretion of VEGF and thus CNV. 
      CONCLUSION: Macular choroidal thinning observed in high myopia with CNV. These 
      findings may suggest that choroidal changes may play a role in the pathogenesis 
      of choroidal neovascularization.
CI  - Copyright (c) 2013 Elsevier Masson SAS. All rights reserved.
FAU - El Matri, L
AU  - El Matri L
AD  - Service d'ophtalmologie B, institut Hedi Rais, boulevard 9-Avril, 1006 Tunis, 
      Tunisie. Electronic address: leila.elmatri@rns.tn.
FAU - Bouladi, M
AU  - Bouladi M
FAU - Chebil, A
AU  - Chebil A
FAU - Kort, F
AU  - Kort F
FAU - Largueche, L
AU  - Largueche L
FAU - Mghaieth, F
AU  - Mghaieth F
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Epaisseur choroidienne foveolaire au SD-OCT dans la myopie forte avec ou sans 
      neovaisseaux choroidiens.
DEP - 20130726
PL  - France
TA  - J Fr Ophtalmol
JT  - Journal francais d'ophtalmologie
JID - 7804128
SB  - IM
MH  - Adult
MH  - Choroid/*pathology
MH  - Choroidal Neovascularization/complications/diagnosis/*pathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Myopia/complications/diagnosis/*pathology
MH  - Organ Size
MH  - Retina/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
OTO - NOTNLM
OT  - Choroid
OT  - Choroidal neovascularization
OT  - Choroide
OT  - High myopia
OT  - Myopie forte
OT  - Neovaisseaux choroidiens
OT  - SD-OCT
EDAT- 2013/07/31 06:00
MHDA- 2014/07/02 06:00
CRDT- 2013/07/31 06:00
PHST- 2012/11/21 00:00 [received]
PHST- 2013/03/06 00:00 [revised]
PHST- 2013/03/11 00:00 [accepted]
PHST- 2013/07/31 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2014/07/02 06:00 [medline]
AID - S0181-5512(13)00220-9 [pii]
AID - 10.1016/j.jfo.2013.03.009 [doi]
PST - ppublish
SO  - J Fr Ophtalmol. 2013 Oct;36(8):687-92. doi: 10.1016/j.jfo.2013.03.009. Epub 2013 
      Jul 26.