PMID- 23896769
OWN - NLM
STAT- MEDLINE
DCOM- 20140425
LR  - 20130902
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 59
IP  - 5
DP  - 2013 Sep-Oct
TI  - Mitral valve repair at the time of continuous-flow left ventricular assist device 
      implantation confers meaningful decrement in pulmonary vascular resistance.
PG  - 469-73
LID - 10.1097/MAT.0b013e31829be026 [doi]
AB  - We hypothesized that the addition of mitral valve replacement or repair (MVR) to 
      implantation of continuous-flow left ventricular assist device (cf-LVAD) may 
      further decrease pulmonary vascular resistance (PVR) over Heartmate II (HMII) 
      implantation alone. Patients undergoing MVR with concomitant HMII implantation 
      were compared with those undergoing HMII implantation alone. Of the 57 patients 
      undergoing cf-LVAD implantation, 21 (36.8%) underwent concomitant MVR and 36 
      (63.2%) underwent cf-LVAD implantation alone. Patients receiving MVR had greater 
      decrement in PVR (59.4% vs. 35.2%, p = 0.01). Decrease in end-diastolic diameter 
      was greater for patients receiving MVR but did not reach statistical significance 
      (18.2 vs. 13.5 mm, p = 0.33). Duration of mechanical ventilation (121.6 vs. 181.4 
      hours, p = 0.45) and inotropic support (162.4 vs. 153.2 hours, p = 0.86), change 
      in creatinine (0.19 vs. -0.26 mg/dl, p = 0.34), increase in bilirubin (2.54 vs. 
      1.55 mg/dl, p = 0.63), intensive care unit stay (168.0 vs. 231.5 hours, p = 
      0.38), and overall length of stay (32.0 vs. 42.5 days, p = 0.75) were similar. 
      There was no difference in survival at 3 months (89.7% vs. 83.3%) and 1 year 
      (83.7 vs. 67.3%, p = 0.34). Addition of MVR may result in greater decrement of 
      PVR than HMII implantation alone. This may permit certain patients thought to be 
      ineligible for transplantation to become candidates.
FAU - Taghavi, Sharven
AU  - Taghavi S
AD  - Department of Surgery, Temple University Hospital, Philadelphia, Pennsylvania, 
      USA.
FAU - Hamad, Eman
AU  - Hamad E
FAU - Wilson, Lynn
AU  - Wilson L
FAU - Clark, Rachael
AU  - Clark R
FAU - Jayarajan, Senthil N
AU  - Jayarajan SN
FAU - Uriel, Nir
AU  - Uriel N
FAU - Goldstein, Daniel J
AU  - Goldstein DJ
FAU - Takayama, Hiroo
AU  - Takayama H
FAU - Naka, Yoshifumi
AU  - Naka Y
FAU - Mangi, Abeel A
AU  - Mangi AA
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
RN  - AYI8EX34EU (Creatinine)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Aged
MH  - Aortic Valve/pathology
MH  - Bilirubin/metabolism
MH  - *Cardiac Surgical Procedures
MH  - Cohort Studies
MH  - Creatinine/metabolism
MH  - Diastole
MH  - Female
MH  - Heart Failure/surgery
MH  - Heart Ventricles/*pathology
MH  - *Heart-Assist Devices
MH  - Humans
MH  - Intensive Care Units
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/*surgery
MH  - Mitral Valve Insufficiency/surgery
MH  - Respiration, Artificial
MH  - Tricuspid Valve Insufficiency/surgery
MH  - *Vascular Resistance
EDAT- 2013/07/31 06:00
MHDA- 2014/04/26 06:00
CRDT- 2013/07/31 06:00
PHST- 2013/07/31 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2014/04/26 06:00 [medline]
AID - 10.1097/MAT.0b013e31829be026 [doi]
PST - ppublish
SO  - ASAIO J. 2013 Sep-Oct;59(5):469-73. doi: 10.1097/MAT.0b013e31829be026.