PMID- 23898276
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130730
LR  - 20211021
IS  - 1662-6575 (Print)
IS  - 1662-6575 (Electronic)
IS  - 1662-6575 (Linking)
VI  - 6
IP  - 2
DP  - 2013 May
TI  - Radiation-induced esophagitis exacerbated by everolimus.
PG  - 320-4
LID - 10.1159/000353309 [doi]
AB  - BACKGROUND: Everolimus, a potent mammalian target of rapamycin (mTOR) inhibitor, 
      has shown anticancer activity against various types of cancer, including renal 
      cell carcinoma (RCC); however, little information is available on the efficacy 
      and safety of the combination of everolimus and radiotherapy. We report a case of 
      radiation-induced esophagitis that might have been exacerbated by the sequential 
      administration of everolimus. CASE PRESENTATION: A 63-year-old Japanese man with 
      RCC complained of back pain, and magnetic resonance imaging revealed vertebral 
      metastases. He received radiotherapy (30 Gy/10 fractions) to the T6-10 vertebrae. 
      Everolimus was administered immediately after the completion of radiotherapy. One 
      week later, he complained of dysphagia, nausea and vomiting. An endoscopic 
      examination of the esophagus showed erosive esophagitis in the middle to lower 
      portions of his thoracic esophagus, corresponding to the irradiation field. 
      CONCLUSION: Clinicians should be aware that everolimus might lead to the 
      unexpected exacerbation of radiation toxicities.
FAU - Miura, Yuji
AU  - Miura Y
AD  - Departments of Medical Oncology, Toranomon Hospital, Tokyo, Japan.
FAU - Suyama, Koichi
AU  - Suyama K
FAU - Shimomura, Akihiko
AU  - Shimomura A
FAU - Miyakawa, Jimpei
AU  - Miyakawa J
FAU - Kobayashi, Hiroki
AU  - Kobayashi H
FAU - Uki, Akiyoshi
AU  - Uki A
FAU - Okaneya, Toshikazu
AU  - Okaneya T
FAU - Takano, Toshimi
AU  - Takano T
LA  - eng
PT  - Case Reports
DEP - 20130615
PL  - Switzerland
TA  - Case Rep Oncol
JT  - Case reports in oncology
JID - 101517601
PMC - PMC3725027
OTO - NOTNLM
OT  - Mammalian target of rapamycin
OT  - Radiation recall syndrome
OT  - Renal cell carcinoma
EDAT- 2013/07/31 06:00
MHDA- 2013/07/31 06:01
PMCR- 2013/06/15
CRDT- 2013/07/31 06:00
PHST- 2013/07/31 06:00 [entrez]
PHST- 2013/07/31 06:00 [pubmed]
PHST- 2013/07/31 06:01 [medline]
PHST- 2013/06/15 00:00 [pmc-release]
AID - cro-0006-0320 [pii]
AID - 10.1159/000353309 [doi]
PST - epublish
SO  - Case Rep Oncol. 2013 Jun 15;6(2):320-4. doi: 10.1159/000353309. Print 2013 May.