PMID- 23899470
OWN - NLM
STAT- MEDLINE
DCOM- 20140320
LR  - 20161125
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 34
IP  - 10
DP  - 2013 Oct
TI  - Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 
      expression in trophoblasts: a possible link between oxidative stress and 
      preeclampsia.
PG  - 949-52
LID - S0143-4004(13)00584-5 [pii]
LID - 10.1016/j.placenta.2013.06.308 [doi]
AB  - Accumulation of advanced oxidation protein products (AOPPs) is prevalent in 
      obesity, advanced maternal age, diabetes mellitus, and polycystic ovary syndrome. 
      Alterations in the regulation and signaling of angiogenic pathways have been 
      recognized as a link between these conditions and pre-eclampsia. To investigate 
      the possible impact of AOPPs on soluble Fms-like tyrosine kinase 1 (sFlt-1) 
      expression in trophoblasts. A trophoblast cell line (HRT-8/SVneo) was treated 
      with various concentrations of AOPPs. The mRNA expression of sFlt-1, vascular 
      endothelial growth factor (VEGF), and placental growth factor (PlGF) in 
      trophoblasts were measured with the use of real-time polymerase chain reaction; 
      and the secretion of sFlt-1, VEGF, and PlGF protein from trophoblasts were 
      detected with the use of ELISA. Exposure of HRT-8/SVneo cells to AOPPs induced 
      overexpression of sFlt-1 at mRNA and protein levels in a dose dependent manner. 
      These effects could be inhibited by apocynin, an inhibitors of NADPH oxidase. Our 
      data identified AOPPs as a class of important mediator in the regulation and 
      signaling of angiogenic pathways of trophoblasts. Accumulation of AOPPs might 
      contributes to the pathogenesis of preeclampsia by promoting sFlt-1 production in 
      trophoblasts.
CI  - Copyright (c) 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Huang, Q T
AU  - Huang QT
AD  - Division of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical 
      University, Guangzhou 510515, China.
FAU - Wang, S S
AU  - Wang SS
FAU - Zhang, M
AU  - Zhang M
FAU - Huang, L P
AU  - Huang LP
FAU - Tian, J W
AU  - Tian JW
FAU - Yu, Y H
AU  - Yu YH
FAU - Wang, Z J
AU  - Wang ZJ
FAU - Zhong, M
AU  - Zhong M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130727
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
RN  - 0 (Acetophenones)
RN  - 0 (Advanced Oxidation Protein Products)
RN  - 0 (PGF protein, human)
RN  - 0 (Pregnancy Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 144589-93-5 (Placenta Growth Factor)
RN  - B6J7B9UDTR (acetovanillone)
RN  - EC 2.7.10.1 (FLT1 protein, human)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
SB  - IM
MH  - Acetophenones/pharmacology
MH  - Advanced Oxidation Protein Products/*pharmacology
MH  - Cell Line
MH  - Female
MH  - Humans
MH  - Oxidative Stress/drug effects
MH  - Placenta Growth Factor
MH  - Pre-Eclampsia/*etiology
MH  - Pregnancy
MH  - Pregnancy Proteins
MH  - RNA, Messenger/metabolism
MH  - Trophoblasts/drug effects/*metabolism
MH  - Vascular Endothelial Growth Factor A/biosynthesis
MH  - Vascular Endothelial Growth Factor Receptor-1/*biosynthesis
OTO - NOTNLM
OT  - Advanced oxidation protein products
OT  - Soluble Fms-like tyrosine kinase 1
OT  - Trophoblast
EDAT- 2013/08/01 06:00
MHDA- 2014/03/22 06:00
CRDT- 2013/08/01 06:00
PHST- 2013/05/27 00:00 [received]
PHST- 2013/06/20 00:00 [revised]
PHST- 2013/06/25 00:00 [accepted]
PHST- 2013/08/01 06:00 [entrez]
PHST- 2013/08/01 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
AID - S0143-4004(13)00584-5 [pii]
AID - 10.1016/j.placenta.2013.06.308 [doi]
PST - ppublish
SO  - Placenta. 2013 Oct;34(10):949-52. doi: 10.1016/j.placenta.2013.06.308. Epub 2013 
      Jul 27.