PMID- 2390030
OWN - NLM
STAT- MEDLINE
DCOM- 19900926
LR  - 20190918
IS  - 0385-8146 (Print)
IS  - 0385-8146 (Linking)
VI  - 17
IP  - 1
DP  - 1990
TI  - Investigation of the genetic regulation in allergic rhinitis.
PG  - 23-32
AB  - Human leukocyte antigen (HLA) population and family studies were performed to 
      determine whether a specific HLA type is associated with allergic rhinitis. We 
      analyzed hereditary characteristics of allergic rhinitis using 27 nuclear 
      families. According to the results of HLA typing, we concluded that allergic 
      rhinitis is certainly regulated by HLA haplotype linked autosomal recessive 
      inheritance. In addition, the frequency of HLA DQw3 antigen, one of the HLA class 
      II antigens, was higher in the patients allergic to Dermatophagoides farinae, 
      Japanese cedar pollen and/or orchard grass pollen than in non-allergic controls. 
      Secondly, the HLA DQw3 antigen was analyzed in detail by means of HLA DNA typing. 
      Regardless of the type of cDNA probes or restriction enzyme, the serologically 
      defined HLA DQw3 region was highly polymorphic at the DNA level. Furthermore, 
      when we used DQ beta as a probe and BamHI as a restriction enzyme, the 8.1 and 
      6.3 kb restricted fragments were detected in lower frequency and 3.5 kb fragment 
      in higher frequency in the patients of allergic rhinitis than in non-allergic 
      controls. Further studies by the cloning of these fragments in the patients and 
      the controls to clarify their function may be necessary to define molecular 
      mechanism of the onset of allergic rhinitis.
FAU - Sadanaga, Y
AU  - Sadanaga Y
AD  - Department of Otolaryngology, Kumamoto University School of Medicine, Japan.
FAU - Uno, M
AU  - Uno M
FAU - Kitao, Y
AU  - Kitao Y
FAU - Ishikawa, T
AU  - Ishikawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blotting, Southern
MH  - Data Collection
MH  - *Family
MH  - Female
MH  - *Genetic Linkage
MH  - HLA-DQ Antigens/analysis
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Pedigree
MH  - Polymorphism, Genetic
MH  - Rhinitis, Allergic, Perennial/epidemiology/*genetics/immunology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - S0385-8146(12)80017-4 [pii]
AID - 10.1016/s0385-8146(12)80017-4 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 1990;17(1):23-32. doi: 10.1016/s0385-8146(12)80017-4.