PMID- 23901717
OWN - NLM
STAT- MEDLINE
DCOM- 20130903
LR  - 20130801
IS  - 0030-9982 (Print)
IS  - 0030-9982 (Linking)
VI  - 63
IP  - 7
DP  - 2013 Jul
TI  - Is depression an inflammatory condition? A review of available evidence.
PG  - 899-906
AB  - The current review examines the relationship between depression and the 
      inflammatory immune response. Mood disorders are a significant cause of morbidity 
      and the etiology of depression is still not clearly understood. Many studies have 
      shown links between inflammatory cytokines and mood disorders, including elevated 
      level of cytokines like tumour necrosis factor-alpha (TNF alpha), Interleukins 
      (IL-1,IL-6) and others. Raised levels of cytokines have been shown to increase 
      depressive behaviour in animal models, while many anti-depressants reverse this 
      behaviour alongside reducing the Central Nervous System (CNS) inflammatory 
      response and reduction in the amounts of inflammatory cytokines. Cytokines reduce 
      neurogenesis, Brain Derived Neurotrophic Factor (BDNF) and neuronal plasticity in 
      the CNS, while many anti-depressants have been shown to reverse these processes. 
      The considerations of anti-depressants as anti-inflammatory agents, and 
      implication of other anti-inflammatory therapeutics for the treatment of 
      depression are pointed out.
FAU - Hashmi, Ali Madeeh
AU  - Hashmi AM
AD  - Department of Psychiatry, King Edward Medical University/Mayo Hospital, Lahore. 
      ahashmi39@gmail.com
FAU - Butt, Zeeshan
AU  - Butt Z
FAU - Umair, Muhammad
AU  - Umair M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Pakistan
TA  - J Pak Med Assoc
JT  - JPMA. The Journal of the Pakistan Medical Association
JID - 7501162
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines/*metabolism
MH  - *Depression/etiology/immunology/metabolism
MH  - Humans
MH  - Inflammation/*immunology/metabolism
EDAT- 2013/08/02 06:00
MHDA- 2013/09/04 06:00
CRDT- 2013/08/02 06:00
PHST- 2013/08/02 06:00 [entrez]
PHST- 2013/08/02 06:00 [pubmed]
PHST- 2013/09/04 06:00 [medline]
AID - 4302 [pii]
PST - ppublish
SO  - J Pak Med Assoc. 2013 Jul;63(7):899-906.