PMID- 23902401
OWN - NLM
STAT- MEDLINE
DCOM- 20140310
LR  - 20221207
IS  - 1557-8593 (Electronic)
IS  - 1520-9156 (Print)
IS  - 1520-9156 (Linking)
VI  - 15
IP  - 8
DP  - 2013 Aug
TI  - Serum adiponectin helps to differentiate type 1 and type 2 diabetes among young 
      Asian Indians.
PG  - 696-702
LID - 10.1089/dia.2012.0306 [doi]
AB  - OBJECTIVE: This study assessed whether serum adiponectin could be used as a 
      biochemical marker to differentiate type 1 diabetes mellitus (T1DM) from type 2 
      diabetes mellitus (T2DM) among young Asian Indians. RESEARCH DESIGN AND METHODS: 
      We recruited age- and sex-matched individuals with physician-diagnosed T1DM 
      (n=70) and T2DM (n=72). All were 12-27 years of age with a duration of diabetes 
      of >2 years, at a large tertiary-care diabetes center in Chennai, southern India. 
      Age- and sex-matched individuals with normal glucose tolerance (NGT) (n=68) were 
      selected from an ongoing population study. NGT was defined using World Health 
      Organization criteria. Serum total adiponectin was measured by enzyme-linked 
      immunosorbent assay. Receiver operating characteristic (ROC) curves were used to 
      identify adiponectin cut points for discriminating T1DM from T2DM. RESULTS: 
      Adiponectin levels were higher in T1DM and lower in T2DM compared with the NGT 
      group (9.89, 3.88, and 6.84 mug/mL, respectively; P<0.001). In standardized 
      polytomous regression models, adiponectin was associated with T1DM (odds ratio 
      [OR]=1.131 per SD; 95% confidence interval [CI], 1.025-1.249) and T2DM (OR=0.628 
      per SD; 95% CI, 0.504-0.721) controlled for age, gender, waist circumference, 
      body mass index, hypertension, glycated hemoglobin, total cholesterol, serum 
      triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein 
      cholesterol, family history of T2DM, and estimated glomerular filtration rate. 
      Using ROC analysis, an adiponectin cut point of 5.1 mug/mL had a C statistic of 
      0.886 (95% CI, 0.836-0.953), sensitivity of 80.6%, and specificity of 80.6% to 
      differentiate T1DM from T2DM. Using the 5.1 mug/mL cut point, 80.6% of T1DM and 
      81.8% of T2DM would be correctly classified. CONCLUSIONS: Serum adiponectin is a 
      useful biochemical marker for differentiating T1DM and T2DM among young Asian 
      Indians.
FAU - Gokulakrishnan, Kuppan
AU  - Gokulakrishnan K
AD  - Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, 
      WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, 
      IDF Centre for Education, Gopalapuram, Chennai, India.
FAU - Aravindhan, Vivekanandhan
AU  - Aravindhan V
FAU - Amutha, Anandakumar
AU  - Amutha A
FAU - Abhijit, Shiny
AU  - Abhijit S
FAU - Ranjani, Harish
AU  - Ranjani H
FAU - Anjana, Ranjit Mohan
AU  - Anjana RM
FAU - Unnikrishnan, Ranjith
AU  - Unnikrishnan R
FAU - Miranda, Priya
AU  - Miranda P
FAU - Narayan, K M Venkat
AU  - Narayan KM
FAU - Mohan, Viswanathan
AU  - Mohan V
LA  - eng
GR  - 1 D43 HD065249/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130731
PL  - United States
TA  - Diabetes Technol Ther
JT  - Diabetes technology & therapeutics
JID - 100889084
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adolescent
MH  - Adult
MH  - Asian People
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Child
MH  - Diabetes Mellitus, Type 1/blood/complications/*diagnosis/drug therapy
MH  - Diabetes Mellitus, Type 2/blood/complications/*diagnosis/drug therapy
MH  - Diagnosis, Differential
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - India
MH  - Male
MH  - Overweight/complications
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Young Adult
PMC - PMC3746282
EDAT- 2013/08/02 06:00
MHDA- 2014/03/13 06:00
PMCR- 2014/08/01
CRDT- 2013/08/02 06:00
PHST- 2013/08/02 06:00 [entrez]
PHST- 2013/08/02 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - 10.1089/dia.2012.0306 [pii]
AID - 10.1089/dia.2012.0306 [doi]
PST - ppublish
SO  - Diabetes Technol Ther. 2013 Aug;15(8):696-702. doi: 10.1089/dia.2012.0306. Epub 
      2013 Jul 31.