PMID- 23902981
OWN - NLM
STAT- MEDLINE
DCOM- 20140221
LR  - 20201209
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 36
IP  - 8
DP  - 2013
TI  - Effect of eriodictyol on the development of atopic dermatitis-like lesions in ICR 
      mice.
PG  - 1375-9
AB  - Atopic dermatitis (AD) is a chronic, allergic, and inflammatory skin disease 
      associated with eczema and dermatitis symptoms. Our previous studies have 
      reported that eriodictyol extract inhibits immunoglobulin E (IgE)/Ag-induced type 
      I hypersensitivity by suppressing the activation of proinflammatory cytokines, 
      such as interleukin-4 (IL-4), and the expression of ceramide kinase. In this 
      study, we investigated the inhibitory effect of eriodictyol on 
      2,4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in ICR mice. 
      Treatment with 2 mg/mL eriodictyol for DNCB-induced AD-like skin lesions in ICR 
      mice improved scratching behavior and skin severity score. Histological analysis 
      demonstrated that thickening of the skin lesions were significantly reduced in 
      the eriodictyol-treated group. Also, eriodictyol suppressed the DNCB-mediated 
      elevation of IgE serum levels. These results suggest that eriodictyol may be a 
      potential therapeutic resource for AD and an adjunctive agent to control 
      itchiness in AD.
FAU - Park, Sae-Jin
AU  - Park SJ
AD  - Division of Biological Science and Technology, College of Science and Technology, 
      Yonsei University, Wonju 220-710, Korea.
FAU - Lee, Yong-Hyeon
AU  - Lee YH
FAU - Lee, Kwang Ho
AU  - Lee KH
FAU - Kim, Tack-Joong
AU  - Kim TJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Flavanones)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - Q520486B8Y (eriodictyol)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*therapeutic use
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Behavior, Animal/drug effects
MH  - Dermatitis, Atopic/blood/chemically induced/*drug therapy/pathology
MH  - Dinitrochlorobenzene
MH  - Flavanones/*therapeutic use
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Pruritus/blood/chemically induced/*drug therapy/pathology
MH  - Skin/pathology
EDAT- 2013/08/02 06:00
MHDA- 2014/02/22 06:00
CRDT- 2013/08/02 06:00
PHST- 2013/08/02 06:00 [entrez]
PHST- 2013/08/02 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - DN/JST.JSTAGE/bpb/b13-00296 [pii]
AID - 10.1248/bpb.b13-00296 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2013;36(8):1375-9. doi: 10.1248/bpb.b13-00296.