PMID- 23903678
OWN - NLM
STAT- MEDLINE
DCOM- 20141003
LR  - 20211021
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 46
IP  - 7
DP  - 2013 Jul
TI  - Genetic analysis of the ELOVL6 gene polymorphism associated with type 2 diabetes 
      mellitus.
PG  - 623-8
LID - S0100-879X2013005033103 [pii]
LID - 10.1590/1414-431X20133103 [doi]
AB  - Recent animal studies have indicated that overexpression of the elongation of 
      long-chain fatty acids family member 6 (Elovl6) gene can cause insulin resistance 
      and beta-cell dysfunction. These are the major factors involved in the development 
      of type 2 diabetes mellitus (T2DM). To identify the relationship between single 
      nucleotide polymorphisms (SNP) of ELOVL6 and T2DM pathogenesis, we conducted a 
      case-control study of 610 Han Chinese individuals (328 newly diagnosed T2DM and 
      282 healthy subjects). Insulin resistance and islet first-phase secretion 
      function were evaluated by assessment of insulin resistance in a homeostasis 
      model (HOMA-IR) and an arginine stimulation test. Three SNPs of the ELOVL6 gene 
      were genotyped with polymerase chain reaction-restriction fragment length 
      polymorphism, with DNA sequencing used to confirm the results. Only genotypes TT 
      and CT of the ELOVL6 SNP rs12504538 were detected in the samples. Genotype CC was 
      not observed. The T2DM group had a higher frequency of the C allele and the CT 
      genotype than the control group. Subjects with the CT genotype had higher HOMA-IR 
      values than those with the TT genotype. In addition, no statistical significance 
      was observed between the genotype and allele frequencies of the control and T2DM 
      groups for SNPs rs17041272 and rs6824447. The study indicated that the ELOVL6 
      gene polymorphism rs12504538 is associated with an increased risk of T2DM, 
      because it causes an increase in insulin resistance.
FAU - Liu, Y
AU  - Liu Y
AD  - Qingdao University, Department of Endocrinology, The Affiliated Hospital of 
      Medical College, China.
FAU - Wang, F
AU  - Wang F
FAU - Yu, X L
AU  - Yu XL
FAU - Miao, Z M
AU  - Miao ZM
FAU - Wang, Z C
AU  - Wang ZC
FAU - Chen, Y
AU  - Chen Y
FAU - Wang, Y G
AU  - Wang YG
LA  - eng
PT  - Journal Article
DEP - 20130722
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (ELOVL6 protein, human)
RN  - EC 2.3.1.- (Acetyltransferases)
RN  - EC 2.3.1.- (Fatty Acid Elongases)
SB  - IM
MH  - Acetyltransferases/*genetics
MH  - Adult
MH  - China/ethnology
MH  - Diabetes Mellitus, Type 2/ethnology/*genetics
MH  - Fatty Acid Elongases
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Insulin Resistance/genetics
MH  - Insulin-Secreting Cells/pathology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide/*genetics
PMC - PMC3859333
EDAT- 2013/08/02 06:00
MHDA- 2014/10/04 06:00
PMCR- 2013/08/10
CRDT- 2013/08/02 06:00
PHST- 2013/03/13 00:00 [received]
PHST- 2013/05/15 00:00 [accepted]
PHST- 2013/08/02 06:00 [entrez]
PHST- 2013/08/02 06:00 [pubmed]
PHST- 2014/10/04 06:00 [medline]
PHST- 2013/08/10 00:00 [pmc-release]
AID - S0100-879X2013005033103 [pii]
AID - 10.1590/1414-431X20133103 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2013 Jul;46(7):623-8. doi: 10.1590/1414-431X20133103. Epub 
      2013 Jul 22.