PMID- 23904312
OWN - NLM
STAT- MEDLINE
DCOM- 20140313
LR  - 20190319
IS  - 1942-7522 (Electronic)
IS  - 0145-5613 (Linking)
VI  - 92
IP  - 7
DP  - 2013 Jul
TI  - Synovial sarcoma of the larynx treated by supraglottic laryngectomy: case report 
      and literature review.
PG  - E20-6
AB  - We describe a case of synovial sarcoma of the larynx, and we discuss the use of 
      fluorescence in situ hybridization (FISH) in confirming the diagnosis. The 
      patient was a 21-year-old woman who presented with a recurrence of a previously 
      resected supraglottic tumor of the aryepiglottic folds. A horizontal supraglottic 
      laryngectomy was performed, and the 0.5-cm tumor was resected. Histopathologic 
      study suggested that it was a biphasic malignant tumor compatible with a synovial 
      sarcoma. The diagnosis of synovial sarcoma was confirmed by FISH 
      immunohistochemistry with the use of an SYT break-apart probe. The patient 
      recovered satisfactorily, but at follow-up 5 years and 4 months later, tumoral 
      activity was evident in the left side of the neck. A biopsy found that 5 lymph 
      nodes contained a metastasis of the synovial sarcoma. Again, a bilateral neck 
      dissection was performed, and it revealed that 16 of 16 right-side nodes and 36 
      of 36 left-side nodes were negative. Two months later, the patient received 46 Gy 
      of radiotherapy in 23 sessions. She remained free of disease during 2 more years 
      of follow-up. Synovial sarcoma of the larynx is a rare entity. Organ preservation 
      seems to be indicated in these cases. The histologic diagnosis may be difficult. 
      In this case, the identification of a genetic mutation corroborated the 
      diagnosis.
FAU - Luna-Ortiz, Kuauhyama
AU  - Luna-Ortiz K
AD  - Department of Head and Neck Surgery, Instituto Nacional de Cancerologia, Mexico 
      City, Mexico. kauauhyama@yahoo.com.mx
FAU - Cano-Valdez, Ana Maria
AU  - Cano-Valdez AM
FAU - da Cunha, Isabela Werneck
AU  - da Cunha IW
FAU - Mosqueda-Taylor, Adalberto
AU  - Mosqueda-Taylor A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ear Nose Throat J
JT  - Ear, nose, & throat journal
JID - 7701817
SB  - IM
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Laryngeal Neoplasms/*diagnosis/radiotherapy/surgery
MH  - Laryngectomy/methods
MH  - Lymphatic Metastasis/radiotherapy
MH  - Neck Dissection
MH  - Neoplasm Recurrence, Local/*diagnosis/radiotherapy/surgery
MH  - Sarcoma, Synovial/*diagnosis/radiotherapy/surgery
MH  - Young Adult
EDAT- 2013/08/02 06:00
MHDA- 2014/03/14 06:00
CRDT- 2013/08/02 06:00
PHST- 2013/08/02 06:00 [entrez]
PHST- 2013/08/02 06:00 [pubmed]
PHST- 2014/03/14 06:00 [medline]
AID - 10.1177/014556131309200717 [doi]
PST - ppublish
SO  - Ear Nose Throat J. 2013 Jul;92(7):E20-6. doi: 10.1177/014556131309200717.