PMID- 23905383
OWN - NLM
STAT- MEDLINE
DCOM- 20140418
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 33
IP  - 5
DP  - 2013 May
TI  - [Xuefu zhuyu oral liquid intervened stress-stimulated depression model rats].
PG  - 638-40
AB  - OBJECTIVE: To observe effects of xuefu zhuyu Oral Liquid (XZOL) on the brain 
      behavior and monoamine neurotransmitter 5-HT, and brain derived neurotrophic 
      factor (BDNF) content on depression model rats. METHODS: Male SD rats were 
      randomly divided into the control group, the model group, the XZOL group, and the 
      Deanxit Tablet group, 12 in each group. The depressive rat model was established 
      by chronic unpredictable mild stress method. XZOL was administered to rats in the 
      XZOL group by gastro-gavage, while Deanxit Tablet was given to those in the 
      Deanxit Tablet group by gastrogavage. The intervention lasted for two weeks. The 
      behavioral changes were observed by sucrose water consumption test and open-field 
      test. The 5-HT and BDNF contents were detected using ELISA. RESULTS: After 
      chronic stress stimulus, experimental rats in the model group might have abnormal 
      behavioral changes and lowered 5-HT content, showing statistical difference when 
      compared with the control group (P <0.01). No obvious change in stimulated rats' 
      behavior after intervention of XZOL and Deanxit Tablet. 5-HT content was not 
      obviously reduced (P>0.05). Besides, XZOL was superior to Deanxit Tablet in 
      increasing the 5-HT content (P<0.05). But the brain BDNF level of rats in the 
      model group was not statistically different from that of rats in the model group 
      (P >0.05), while the brain BDNF level of rats in the XZOL group and the Deanxit 
      Tablet group was lower than that of rats in the model group (P <0.01). 
      CONCLUSIONS: Stress can lead to behavioral changes and lowered 5-HT content of 
      rats. The intervention of XZOL could fight against depression-induced behavioral 
      changes and increase 5-HT content. But it did not significantly affect the brain 
      BDNF level. We inferred that it might not effect through the BDNF pathway.
FAU - Lu, Ling-ling
AU  - Lu LL
AD  - Department of Traditional Chinese Medicine, Ruijin Hospital, Medical College of 
      Shanghai Jiaotong University, Shanghai 200025, China
FAU - Shen, Xiao-Heng
AU  - Shen XH
FAU - Chen, Jing-xian
AU  - Chen JX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Xue-Fu-Zhu-Yu decoction)
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depression/*drug therapy
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/metabolism
MH  - Stress, Psychological/*metabolism
EDAT- 2013/08/03 06:00
MHDA- 2014/04/20 06:00
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2013/08/03 06:00 [pubmed]
PHST- 2014/04/20 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 May;33(5):638-40.