PMID- 23906230
OWN - NLM
STAT- MEDLINE
DCOM- 20140318
LR  - 20151119
IS  - 2410-8650 (Electronic)
IS  - 1607-551X (Linking)
VI  - 29
IP  - 8
DP  - 2013 Aug
TI  - Promotion of thermal analgesia and neuropeptidergic skin reinnervation by 
      4-methylcatechol in resiniferatoxin-induced neuropathy.
PG  - 405-11
LID - S1607-551X(12)00358-0 [pii]
LID - 10.1016/j.kjms.2012.12.001 [doi]
AB  - To investigate whether 4-methylcatechol (4MC) could decrease the duration of the 
      thermosensation disorder and promote the innervation of peptidergic 
      intraepidermal nerve fibers (IENFs), we developed a resiniferatoxin (RTX)-induced 
      neuropathic mouse model with thermal analgesia and skin denervation that was 
      followed by daily 4MC treatment. On day 7 after RTX administration (RTXd7), the 
      substance P (SP)(+) IENFs were completely depleted compared with the vehicle 
      group (p < 0.0001), whereas the calcitonin gene-related peptide (CGRP)(+) IENFs 
      were dramatically, but not completely, depleted (p < 0.0001). While SP(+) IENFs 
      remained depleted (p = 0.0043), CGRP(+) IENFs were recovered by RTXd84 (p = 
      0.78). 4MC had no effect on the reinnervation of SP(+) IENFs, but markedly 
      promoted the reinnervation of CGRP(+) IENFs on RTXd35 (p = 0.035). On RTXd56, 
      CGRP(+) IENFs were comparable with the vehicle group (p = 0.39). In addition, 4MC 
      normalized thermal analgesia on RTXd35 compared with RTX group (p = 0.007). In 
      the current study, the significant promotion of reinnervation of CGRP(+) IENFs 
      and thermal latencies on RTXd35 by 4MC indicated that CGRP(+) IENFs were 
      responsible for the thermal transmission in chronic phase of RTX-induced 
      neuropathy.
CI  - Copyright (c) 2012. Published by Elsevier B.V.
FAU - Hsiao, Tin-Hsin
AU  - Hsiao TH
AD  - Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical 
      University, Taiwan. ylhsieh@kmu.edu.tw
FAU - Fu, Yaw-Syan
AU  - Fu YS
FAU - Ho, Wan-Yi
AU  - Ho WY
FAU - Chen, Tzi-Hsuan
AU  - Chen TH
FAU - Hsieh, Yu-Lin
AU  - Hsieh YL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130206
PL  - China (Republic : 1949- )
TA  - Kaohsiung J Med Sci
JT  - The Kaohsiung journal of medical sciences
JID - 100960562
RN  - 0 (Catechols)
RN  - 0 (Diterpenes)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Neurotoxins)
RN  - 12GLI7JGB3 (4-methylcatechol)
RN  - A5O6P1UL4I (resiniferatoxin)
SB  - IM
MH  - Analgesia/*methods
MH  - Animals
MH  - Catechols/*pharmacology
MH  - Denervation/methods
MH  - Disease Models, Animal
MH  - Diterpenes/*toxicity
MH  - Hot Temperature
MH  - Male
MH  - Mice
MH  - Nerve Regeneration/*drug effects
MH  - Neuroprotective Agents/pharmacology
MH  - Neurotoxins/toxicity
MH  - Pain Threshold/*drug effects
MH  - Skin/*innervation
OTO - NOTNLM
OT  - 4-Methylcatechol
OT  - Calcitonin gene-related peptide
OT  - Resiniferatoxin
OT  - Substance P
OT  - Transient receptor potential vanilloid subtype 1
EDAT- 2013/08/03 06:00
MHDA- 2014/03/19 06:00
CRDT- 2013/08/03 06:00
PHST- 2012/07/05 00:00 [received]
PHST- 2012/09/17 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2013/08/03 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
AID - S1607-551X(12)00358-0 [pii]
AID - 10.1016/j.kjms.2012.12.001 [doi]
PST - ppublish
SO  - Kaohsiung J Med Sci. 2013 Aug;29(8):405-11. doi: 10.1016/j.kjms.2012.12.001. Epub 
      2013 Feb 6.