PMID- 23906337
OWN - NLM
STAT- MEDLINE
DCOM- 20141026
LR  - 20130930
IS  - 1474-8673 (Electronic)
IS  - 1474-8665 (Linking)
VI  - 33
IP  - 3-4
DP  - 2013 Oct
TI  - Influence of ketanserin on the effects of methylenedioxymethamphetamine on body 
      temperature in the mouse.
PG  - 35-41
LID - 10.1111/aap.12009 [doi]
AB  - (1) We have investigated the ability of the 5HT2 -receptor antagonist ketanserin 
      to affect the hyperthermia produced by methylenedioxymethamphetamine (MDMA) in 
      conscious mice and examined whether alpha1 -adrenoceptor antagonist actions are 
      involved. (2) Mice were implanted with intra-abdominal temperature probes under 
      anaesthesia and allowed 2 weeks recovery. MDMA (20 mg kg(-1) ) was administered 
      subcutaneously 30 min after vehicle or test antagonist and effects on body 
      temperature monitored by telemetry. (3) Following vehicle, MDMA produced a slowly 
      developing hyperthermia, reaching a maximum increase of 1.24  degrees C at 150 min 
      postinjection. Ketanserin (0.5 mg kg(-1) ) revealed a significant and marked 
      early hypothermia to MDMA, an effect that is mimicked by the alpha1 -adrenoceptor 
      antagonist prazosin (0.1 mg kg(-1) ). (4) Functional studies revealed antagonist 
      actions of ketanserin at alpha1 -adrenoceptors in rat aorta and rat vas deferens in 
      vitro indicative of alpha1 -adrenoceptor antagonist actions at the concentration used 
      in vivo. (5) In conclusion, ketanserin (0.5 mg kg(-1) ) modulates the 
      hyperthermic actions of MDMA in mice. Although we cannot rule out additional 
      actions at 5HT2 -receptors, the actions of ketanserin are consistent with alpha1 
      -adrenoceptor antagonism. There is no clear evidence from this study that 
      5HT2-receptors mediate the hyperthermic response to MDMA.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Docherty, J R
AU  - Docherty JR
AD  - Department of Physiology, Royal College of Surgeons in Ireland, 123 St Stephen's 
      Green, Dublin, Ireland.
FAU - Bexis, S
AU  - Bexis S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130802
PL  - England
TA  - Auton Autacoid Pharmacol
JT  - Autonomic & autacoid pharmacology
JID - 101157306
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Adrenergic alpha-1 Receptor Antagonists)
RN  - 0 (Serotonin Antagonists)
RN  - 97F9DE4CT4 (Ketanserin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - XM03YJ541D (Prazosin)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/antagonists & inhibitors/pharmacology
MH  - Adrenergic alpha-1 Receptor Antagonists/pharmacology
MH  - Animals
MH  - Aorta/drug effects
MH  - Body Temperature/*drug effects
MH  - Fever/*chemically induced
MH  - Ketanserin/*pharmacology
MH  - Male
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*antagonists & inhibitors/pharmacology
MH  - Prazosin/pharmacology
MH  - Rats
MH  - Serotonin Antagonists/pharmacology
MH  - Vas Deferens/drug effects
OTO - NOTNLM
OT  - 5HT2-receptor
OT  - MDMA
OT  - hyperthermia
OT  - hypothermia
OT  - ketanserin
OT  - alpha1-adrenoceptor
EDAT- 2013/08/03 06:00
MHDA- 2014/10/27 06:00
CRDT- 2013/08/03 06:00
PHST- 2013/03/15 00:00 [received]
PHST- 2013/04/18 00:00 [revised]
PHST- 2013/05/13 00:00 [accepted]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2013/08/03 06:00 [pubmed]
PHST- 2014/10/27 06:00 [medline]
AID - 10.1111/aap.12009 [doi]
PST - ppublish
SO  - Auton Autacoid Pharmacol. 2013 Oct;33(3-4):35-41. doi: 10.1111/aap.12009. Epub 
      2013 Aug 2.