PMID- 23906492
OWN - NLM
STAT- MEDLINE
DCOM- 20140313
LR  - 20191112
IS  - 1488-2353 (Electronic)
IS  - 0147-958X (Linking)
VI  - 36
IP  - 4
DP  - 2013 Aug 1
TI  - Decreased plasma apolipoprotein A-IV levels in patients with acute coronary 
      syndrome.
PG  - E207-15
AB  - PURPOSE: The purpose of this study was to evaluate the relationship between 
      apolipoprotein A-IV (apoA-IV) plasma concentrations and acute coronary syndrome 
      (ACS). METHODS: Plasma apoA-IV concentrations were measured in 115 patients with 
      different types of ACS and in 68 gender- and age-matched control subjects using 
      Enzyme-Linked Immunosorbent Assay (ELISA) kits. The clinical data were collected 
      by an internist, who was blinded to plasma apoA-IV concentrations. RESULTS: 
      Plasma apoA-IV levels in ACS patients were significantly decreased compared to 
      the levels in control subjects (437.0+/-157.5 mug/mL vs. 590.2+/-183.7 mug/mL, 
      P<0.001). An statistically significant decreasing trend of plasma apoA-IV levels 
      from the control subjects, to patients with unstable angina pectoris (UAP) 
      (457.3+/-152.9 mug/mL), to patients with acute myocardial infarction (AMI) 
      (311.7+/-127.8 mug/mL), was observed. Moreover, plasma apoA-IV level was negatively 
      associated with New York Heart Association (NYHA) functional class. NYHA class II 
      (467.2+/-142.1 mug/mL, P<0.001) and class III/IV (368.1+/-170.8 mug/mL, P<0.001) 
      patients had statistically decreased levels of plasma apoA-IV when compared to 
      the control subjects. A stepwise multivariate regression analysis identified 
      types of ACS, NYHA classes, and plasma fibrinogen levels as the most important 
      determinants of plasma apoA-IV levels in ACS patients. CONCLUSIONS: Low plasma 
      apoA-IV levels are associated with ACS, and plasma apoA-IV levels may be a 
      potential treatment target for ACS patients.
FAU - Li, Jiabei
AU  - Li J
AD  - Institute of Cardiovascular Medicine, Xinqiao Hospital, Third Military Medical 
      University, Chongqing, China
FAU - Song, Mingbao
AU  - Song M
FAU - Qian, Dehui
AU  - Qian D
FAU - Lu, Wei
AU  - Lu W
FAU - Wang, Juan
AU  - Wang J
FAU - Jiang, Guoyan
AU  - Jiang G
FAU - Jin, Jun
AU  - Jin J
FAU - Wu, Xiaojing
AU  - Wu X
FAU - Huang, Lan
AU  - Huang L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130801
PL  - Canada
TA  - Clin Invest Med
JT  - Clinical and investigative medicine. Medecine clinique et experimentale
JID - 7804071
RN  - 0 (Apolipoproteins A)
RN  - 0 (apolipoprotein A-IV)
SB  - IM
MH  - Acute Coronary Syndrome/*blood
MH  - Aged
MH  - Apolipoproteins A/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2013/08/03 06:00
MHDA- 2014/03/14 06:00
CRDT- 2013/08/03 06:00
PHST- 2013/08/01 00:00 [received]
PHST- 2013/08/03 06:00 [entrez]
PHST- 2013/08/03 06:00 [pubmed]
PHST- 2014/03/14 06:00 [medline]
AID - 10.25011/cim.v36i4.19954 [doi]
PST - epublish
SO  - Clin Invest Med. 2013 Aug 1;36(4):E207-15. doi: 10.25011/cim.v36i4.19954.