PMID- 23907078
OWN - NLM
STAT- MEDLINE
DCOM- 20140130
LR  - 20240318
IS  - 1538-6724 (Electronic)
IS  - 0031-9023 (Print)
IS  - 0031-9023 (Linking)
VI  - 93
IP  - 12
DP  - 2013 Dec
TI  - Promoting neuroplasticity for motor rehabilitation after stroke: considering the 
      effects of aerobic exercise and genetic variation on brain-derived neurotrophic 
      factor.
PG  - 1707-16
LID - 10.2522/ptj.20130053 [doi]
AB  - Recovery of motor function after stroke involves relearning motor skills and is 
      mediated by neuroplasticity. Recent research has focused on developing 
      rehabilitation strategies that facilitate such neuroplasticity to maximize 
      functional outcome poststroke. Although many molecular signaling pathways are 
      involved, brain-derived neurotrophic factor (BDNF) has emerged as a key 
      facilitator of neuroplasticity involved in motor learning and rehabilitation 
      after stroke. Thus, rehabilitation strategies that optimize BDNF effects on 
      neuroplasticity may be especially effective for improving motor function 
      poststroke. Two potential poststroke rehabilitation strategies that consider the 
      importance of BDNF are the use of aerobic exercise to enhance brain function and 
      the incorporation of genetic information to individualize therapy. Converging 
      evidence demonstrates that aerobic exercise increases BDNF production and 
      consequently enhances learning and memory processes. Nevertheless, a common 
      genetic variant reduces activity-dependent secretion of the BDNF protein. Thus, 
      BDNF gene variation may affect response to motor rehabilitation training and 
      potentially modulate the effects of aerobic exercise on neuroplasticity. This 
      perspective article discusses evidence that aerobic exercise promotes 
      neuroplasticity by increasing BDNF production and considers how aerobic exercise 
      may facilitate the acquisition and retention of motor skills for poststroke 
      rehabilitation. Next, the impact of the BDNF gene val66met polymorphism on motor 
      learning and response to rehabilitation is explored. It is concluded that the 
      effects of aerobic exercise on BDNF and motor learning may be better exploited if 
      aerobic exercise is paired more closely in time with motor training. 
      Additionally, information about BDNF genotype could provide insight into the type 
      and magnitude of effects that aerobic exercise may have across individuals and 
      potentially help guide an individualized prescription of aerobic exercise to 
      enhance motor rehabilitation poststroke.
FAU - Mang, Cameron S
AU  - Mang CS
AD  - C.S. Mang, BPE, MSc, Department of Physical Therapy, Faculty of Medicine, 
      University of British Columbia, Vancouver, British Columbia, Canada.
FAU - Campbell, Kristin L
AU  - Campbell KL
FAU - Ross, Colin J D
AU  - Ross CJ
FAU - Boyd, Lara A
AU  - Boyd LA
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130801
PL  - United States
TA  - Phys Ther
JT  - Physical therapy
JID - 0022623
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*genetics/physiology
MH  - Exercise/*physiology
MH  - Humans
MH  - Motor Skills/*physiology
MH  - Neuronal Plasticity/genetics/*physiology
MH  - Polymorphism, Genetic
MH  - Recovery of Function/genetics/*physiology
MH  - Stroke/metabolism
MH  - *Stroke Rehabilitation
PMC - PMC3870490
EDAT- 2013/08/03 06:00
MHDA- 2014/01/31 06:00
PMCR- 2014/06/01
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2013/08/03 06:00 [pubmed]
PHST- 2014/01/31 06:00 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - ptj.20130053 [pii]
AID - 2013-0053 [pii]
AID - 10.2522/ptj.20130053 [doi]
PST - ppublish
SO  - Phys Ther. 2013 Dec;93(12):1707-16. doi: 10.2522/ptj.20130053. Epub 2013 Aug 1.