PMID- 23907589
OWN - NLM
STAT- MEDLINE
DCOM- 20140310
LR  - 20211021
IS  - 1573-9104 (Electronic)
IS  - 0921-9668 (Linking)
VI  - 68
IP  - 3
DP  - 2013 Sep
TI  - Germinated brown rice extract inhibits adipogenesis through the down-regulation 
      of adipogenic genes in 3T3-L1 adipocytes.
PG  - 274-8
LID - 10.1007/s11130-013-0366-9 [doi]
AB  - The aim of this study was to examine the anti-adipogenic effect of germinated 
      brown rice methanol extract (GBR) in 3T3-L1 adipocytes. The GBR inhibited 
      adipocyte differentiation was measured by Oil Red O staining and 
      glycerol-3-phosphate dehydrogenase (GPDH) activity in a dose-dependent manner 
      without initiating any cytotoxicity. The mRNA levels of adipogenic transcription 
      factors such as CCAAT/enhancer binding protein (C/EBPalpha), proliferator-activated 
      receptorgamma (PPARgamma), and sterol regulatory element-binding protein-1c (SREBP-1c), 
      and adipogenic genes, such as fatty acid synthase (FAS), adipocyte fatty 
      acid-binding protein (aP2), and lipoprotein lipase (LPL), were significantly 
      down-regulated by treatment with GBR when compared to that of untreated control 
      cells. Moreover, tumor necrosis factor-alpha (TNF-alpha) and interlukin-6 (IL-6) mRNA 
      expressions were attenuated by GBR in mature adipocytes. These data suggest that 
      GBR exhibits an anti-adipogenic effect through the suppression of adipogenesis in 
      3T3-L1 adipocytes.
FAU - Ho, Jin-Nyoung
AU  - Ho JN
AD  - Department of Medical Nutrition, Kyung Hee University, Yongin, Korea.
FAU - Son, Mi-Eun
AU  - Son ME
FAU - Lim, Won-Chul
AU  - Lim WC
FAU - Lim, Seung-Taik
AU  - Lim ST
FAU - Cho, Hong-Yon
AU  - Cho HY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Plant Foods Hum Nutr
JT  - Plant foods for human nutrition (Dordrecht, Netherlands)
JID - 8803554
RN  - 0 (Fabp4 protein, mouse)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
RN  - EC 1.1.- (Glycerolphosphate Dehydrogenase)
RN  - EC 2.3.1.85 (Fatty Acid Synthases)
RN  - EC 3.1.1.34 (Lipoprotein Lipase)
SB  - IM
MH  - 3T3-L1 Cells
MH  - Adipocytes/cytology/*drug effects/metabolism
MH  - Adipogenesis/drug effects/*genetics
MH  - Animals
MH  - Cell Differentiation/drug effects
MH  - Down-Regulation
MH  - Fatty Acid Synthases/genetics
MH  - Fatty Acid-Binding Proteins/genetics
MH  - *Germination
MH  - Glycerolphosphate Dehydrogenase/metabolism
MH  - Lipoprotein Lipase/genetics
MH  - Mice
MH  - Oryza/*chemistry
MH  - Plant Extracts/*pharmacology
MH  - RNA, Messenger/analysis
MH  - Seeds/*chemistry/growth & development
MH  - Transcription Factors/genetics
EDAT- 2013/08/03 06:00
MHDA- 2014/03/13 06:00
CRDT- 2013/08/03 06:00
PHST- 2013/08/03 06:00 [entrez]
PHST- 2013/08/03 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - 10.1007/s11130-013-0366-9 [doi]
PST - ppublish
SO  - Plant Foods Hum Nutr. 2013 Sep;68(3):274-8. doi: 10.1007/s11130-013-0366-9.