PMID- 2390805
OWN - NLM
STAT- MEDLINE
DCOM- 19901004
LR  - 20190824
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 17
IP  - 6
DP  - 1990 Jun
TI  - Antidiuretic effects of neurotensin in chloralose anaesthetized dogs.
PG  - 401-12
AB  - 1. Effects of cerebroventricular and/or intravenous infusions of neurotensin 
      (NT), an endogenous tridecapeptide, on haemodynamics and renal function were 
      investigated in chloralose anaesthetized dogs. 2. Cerebroventricular infusions 
      (i.c.v.) of NT (10-6 mol/L and 10-5 mol/L, 0.1 mL/min) for 30 min did not produce 
      any significant alterations in the measured variables. In the vagotomized dogs, 
      intravenous (i.v.) infusion of NT (10(-5) mol/L) at a rate of 0.1 mL/min for 30 
      min significantly lowered the arterial blood pressure and glomerular filtration 
      rate; these effects were accompanied by pronounced reductions in the urine flow 
      and urinary sodium excretion and marked increases in urine osmolality. 3. In the 
      dogs with vagi intact, i.v. infusions of NT failed to produce any alterations in 
      the blood pressure; however, renal effects of NT were essentially identical to 
      those observed in the vagotomized dogs. 4. Infusions of NT (10(-6) mol/L) and/or 
      NT-metabolites NT1-8 and NT8-13 (10(-5) mol/L) directly into the renal artery 
      failed to produce any significant alterations in the urine flow. Antidiuretic 
      effects of i.v. NT were not prevented by acute renal denervation, adrenalectomy, 
      or pretreatment of the animals with naloxone. However, morphine pretreatment 
      completely abolished the hypotensive and anti-diuretic effects of NT. 5. It is 
      proposed that i.v. infusion of NT rapidly facilitates the secretion of an 
      endogenous substance possessing potent antidiuretic properties and opiate 
      mechanisms are involved in mediating such an effect. Although it appears 
      unlikely, a role for vasopressin cannot be ruled out.
FAU - Kivlighn, S D
AU  - Kivlighn SD
AD  - Department of Pharmacology, University of Houston, TX 77204-5515.
FAU - Jandhyala, B S
AU  - Jandhyala BS
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 238BZ29MUE (Chloralose)
RN  - 39379-15-2 (Neurotensin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Anesthesia
MH  - Animals
MH  - Chloralose
MH  - Cisterna Magna
MH  - Diuresis/*drug effects
MH  - Dogs
MH  - Hemodynamics/drug effects
MH  - Infusions, Intravenous
MH  - Infusions, Parenteral
MH  - Molecular Sequence Data
MH  - Neurotensin/*pharmacology
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1990.tb01339.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 1990 Jun;17(6):401-12. doi: 
      10.1111/j.1440-1681.1990.tb01339.x.