PMID- 2390806
OWN - NLM
STAT- MEDLINE
DCOM- 19901004
LR  - 20190824
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 17
IP  - 6
DP  - 1990 Jun
TI  - Relaxation of mesenteric artery of stroke prone spontaneously hypertensive rats 
      by calcium removal.
PG  - 413-25
AB  - 1. The time courses of the relaxation, induced by removal of extracellular Ca2+, 
      of K-depolarized mesenteric artery preparations from stroke prone spontaneously 
      hypertensive rats (SHRSP) and Wistar-Kyoto rats (WKY) were compared. 2. The time 
      course of the decline in extracellular Ca2+ was estimated from the time course of 
      the relaxation and the concentration-response curve of K(+)-depolarized 
      preparations to Ca2+. The time course of the decline in the intracellular free 
      Ca2+ concentration was also estimated from the reported relation between Ca2+ 
      concentration and the contraction of skinned vascular smooth muscle. 3. The time 
      course of relaxation was exponential, the curve being made up of three 
      components. The time course was slower in preparations from SHRSP, especially the 
      first component of the relaxation curve. 4. The time courses of the decline in 
      the intracellular and extracellular Ca2+ concentrations were also exponential, 
      being made up of three components and were also slower in the preparation made 
      from SHRSP. 5. The wall and muscle layer of the mesenteric arteries used in the 
      present experiments were significantly thicker in the SHRSP preparations. 6. 
      Calculation of the half relaxation time, based on the diffusion of Ca2+ across 
      the blood vessel wall, suggested that the slower relaxation in preparations from 
      SHRSP is due largely to the thicker muscle layer, although differences in Ca2+ 
      sequestration by the smooth muscle cells may also be involved.
FAU - Sunano, S
AU  - Sunano S
AD  - Research Institute of Hypertension, Kinki University, Osaka, Japan.
FAU - Shimada, T
AU  - Shimada T
FAU - Moriyama, K
AU  - Moriyama K
FAU - Shimamura, K
AU  - Shimamura K
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - RWP5GA015D (Potassium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Blood Pressure/physiology
MH  - Body Weight/physiology
MH  - Calcium/*physiology
MH  - Cerebrovascular Disorders/*physiopathology
MH  - Disease Susceptibility
MH  - Hypertension/*physiopathology
MH  - In Vitro Techniques
MH  - Mesenteric Arteries/physiopathology
MH  - Potassium/physiology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Vasodilation/*physiology
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
AID - 10.1111/j.1440-1681.1990.tb01340.x [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 1990 Jun;17(6):413-25. doi: 
      10.1111/j.1440-1681.1990.tb01340.x.