PMID- 23911220
OWN - NLM
STAT- MEDLINE
DCOM- 20140414
LR  - 20130909
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 29
IP  - 10
DP  - 2013 Oct
TI  - Autism as a disorder of deficiency of brain-derived neurotrophic factor and 
      altered metabolism of polyunsaturated fatty acids.
PG  - 1175-85
LID - S0899-9007(13)00054-3 [pii]
LID - 10.1016/j.nut.2013.01.012 [doi]
AB  - Autism has a strong genetic and environmental basis in which inflammatory markers 
      and factors concerned with synapse formation, nerve transmission, and information 
      processing such as brain-derived neurotrophic factor (BDNF), polyunsaturated 
      fatty acids (PUFAs): arachidonic (AA), eicosapentaenoic (EPA), and 
      docosahexaenoic acids (DHA) and their products and neurotransmitters: dopamine, 
      serotonin, acetylcholine, gamma-aminobutyric acid, and catecholamines and cytokines 
      are altered. Antioxidants, vitamins, minerals, and trace elements are needed for 
      the normal metabolism of neurotrophic factors, eicosanoids, and 
      neurotransmitters, supporting reports of their alterations in autism. But, the 
      exact relationship among these factors and their interaction with genes and 
      proteins concerned with brain development and growth is not clear. It is 
      suggested that maternal infections and inflammation and adverse events during 
      intrauterine growth of the fetus could lead to alterations in the gene expression 
      profile and proteomics that results in dysfunction of the neuronal function and 
      neurotransmitters, alteration(s) in the metabolism of PUFAs and their metabolites 
      resulting in excess production of proinflammatory eicosanoids and cytokines and a 
      deficiency of anti-inflammatory cytokines and bioactive lipids that ultimately 
      results in the development of autism. Based on these evidences, it is proposed 
      that selective delivery of BDNF and methods designed to augment the production of 
      anti-inflammatory cytokines and eicosanoids and PUFAs may prevent, arrest, or 
      reverse the autism disease process.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Das, Undurti N
AU  - Das UN
AD  - UND Life Sciences, Shaker Heights, OH, USA. Undurti@hotmail.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130730
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Catecholamines)
RN  - 0 (Cytokines)
RN  - 0 (Neurotransmitter Agents)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - 27YG812J1I (Arachidonic Acid)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 333DO1RDJY (Serotonin)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
RN  - N9YNS0M02X (Acetylcholine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Anti-Inflammatory Agents/metabolism
MH  - Arachidonic Acid/*metabolism
MH  - Autistic Disorder/genetics/*metabolism/physiopathology/prevention & control
MH  - Brain-Derived Neurotrophic Factor/*deficiency/metabolism
MH  - Catecholamines/metabolism
MH  - Cytokines/deficiency/metabolism
MH  - Docosahexaenoic Acids/*metabolism
MH  - Dopamine/metabolism
MH  - Eicosapentaenoic Acid/*metabolism
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Neurotransmitter Agents/metabolism
MH  - Nitric Oxide/metabolism
MH  - Serotonin/metabolism
MH  - gamma-Aminobutyric Acid/metabolism
OTO - NOTNLM
OT  - Autism
OT  - Brain-derived neurotrophic factor
OT  - Cytokines
OT  - Inflammation
OT  - Lipoxins
OT  - Memory
OT  - Nitric oxide
OT  - Polyunsaturated fatty acids
OT  - Prostaglandins
OT  - Resolvins
EDAT- 2013/08/06 06:00
MHDA- 2014/04/15 06:00
CRDT- 2013/08/06 06:00
PHST- 2012/10/29 00:00 [received]
PHST- 2012/12/12 00:00 [revised]
PHST- 2013/01/12 00:00 [accepted]
PHST- 2013/08/06 06:00 [entrez]
PHST- 2013/08/06 06:00 [pubmed]
PHST- 2014/04/15 06:00 [medline]
AID - S0899-9007(13)00054-3 [pii]
AID - 10.1016/j.nut.2013.01.012 [doi]
PST - ppublish
SO  - Nutrition. 2013 Oct;29(10):1175-85. doi: 10.1016/j.nut.2013.01.012. Epub 2013 Jul 
      30.