PMID- 23911239
OWN - NLM
STAT- MEDLINE
DCOM- 20140508
LR  - 20131016
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 17
IP  - 11
DP  - 2013 Nov
TI  - The relationship between the human leukocyte antigen system and Crimean-Congo 
      hemorrhagic fever in the Turkish population.
PG  - e1038-41
LID - S1201-9712(13)00217-8 [pii]
LID - 10.1016/j.ijid.2013.06.005 [doi]
AB  - OBJECTIVES: The human leukocyte antigen (HLA) molecules have been shown to be 
      important genetic factors in several diseases. In this study we aimed to evaluate 
      the possible role of HLA genes in the course of Crimean-Congo hemorrhagic fever 
      (CCHF) infection. METHODS: A total of 57 adult patients with CCHF and 43 healthy 
      controls living in the same regions as the patients were included in the study. 
      Severe cases were defined according to previously reported severity criteria. 
      RESULTS: The frequency of HLA-A*02 was found to be significantly higher in the 
      patients than in the healthy controls (p=0.021). However, a significantly lower 
      frequency of HLA-B*27 was observed in the patients than in the healthy controls 
      (p=0.01). The relative risk (RR) of HLA-A*02 allele for CCHF was found to be 1.93 
      (95% confidence interval 1.11 < RR < 3.36). With regard to severe and non-severe 
      cases, there was a significantly greater frequency of HLA-A*23 in severe cases 
      (p=0.014). CONCLUSIONS: The results of this study indicate that while some HLA 
      alleles could constitute a risk factor for acquiring CCHF infection, others could 
      have a protective role against the disease. This study also presents the impact 
      of genetic risk factors on the clinical course of the disease.
CI  - Copyright (c) 2013 International Society for Infectious Diseases. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Akinci, Esragul
AU  - Akinci E
AD  - Ankara Numune Education And Research Hospital, Infectious Diseases and Clinical 
      Microbiology Department, 06100 Sihhiye, Ankara, Turkey. Electronic address: 
      esragulakinci@gmail.com.
FAU - Bodur, Hurrem
AU  - Bodur H
FAU - Musabak, Ugur
AU  - Musabak U
FAU - Sagkan, Rahsan I
AU  - Sagkan RI
LA  - eng
PT  - Journal Article
DEP - 20130730
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics/immunology
MH  - *Hemorrhagic Fever Virus, Crimean-Congo/immunology
MH  - Hemorrhagic Fever, Crimean/*genetics/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Turkey
OTO - NOTNLM
OT  - Crimean-Congo hemorrhagic fever
OT  - Genetic factors
OT  - HLA
EDAT- 2013/08/06 06:00
MHDA- 2014/05/09 06:00
CRDT- 2013/08/06 06:00
PHST- 2013/03/04 00:00 [received]
PHST- 2013/05/29 00:00 [revised]
PHST- 2013/06/03 00:00 [accepted]
PHST- 2013/08/06 06:00 [entrez]
PHST- 2013/08/06 06:00 [pubmed]
PHST- 2014/05/09 06:00 [medline]
AID - S1201-9712(13)00217-8 [pii]
AID - 10.1016/j.ijid.2013.06.005 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2013 Nov;17(11):e1038-41. doi: 10.1016/j.ijid.2013.06.005. Epub 
      2013 Jul 30.