PMID- 23911699
OWN - NLM
STAT- MEDLINE
DCOM- 20140702
LR  - 20220408
IS  - 1872-6623 (Electronic)
IS  - 0304-3959 (Linking)
VI  - 154
IP  - 12
DP  - 2013 Dec
TI  - Effect of conditioned pain modulation on trigeminal somatosensory function 
      evaluated by quantitative sensory testing.
PG  - 2684-2690
LID - 10.1016/j.pain.2013.07.049 [doi]
AB  - The aim of the study was to systematically investigate the effect of 
      craniofacially evoked conditioned pain modulation on somatosensory function using 
      a quantitative sensory testing (QST) protocol applied to the trigeminal area in 
      healthy humans. Pressure pain evoked by a mechanical compressive device was 
      applied as conditioning stimulus (CS) in the craniofacial region, with a pain 
      intensity of 5 on a visual analogue scale (VAS: 0-10 cm) (painful session) or 
      with VAS score of 0 (control session). A full QST battery of 13 parameters was 
      performed as test stimuli on the dominant-side cheek. The individual QST data 
      from 11 men and 12 women were transformed into z scores, and the QST data and z 
      scores were tested using analyses of variance. Analyses of variance of pressure 
      pain threshold (PPT) data (log-transformed values and z scores) indicated 
      significant session (P </= .003) and time (P < .001) effects with a session-time 
      interaction (P < .001), but no main effect of sex (P >/= .053, effect size >/= .166). 
      The session-time interaction showed that the PPTs in the painful session were 
      associated with significantly higher log-transformed PPT values and significantly 
      lower z scores compared with the control session at the time point during CS 
      (hypoalgesia) (P < .001). No other QST parameters were significantly modulated by 
      the CS. Sex differences were not detected in this study; a larger sample size may 
      be needed to further explore this possibility. However, the findings indicate 
      that when extensive QST protocols are applied, PPT may be the most sensitive 
      measure to detect endogenous pain inhibitory mechanisms.
CI  - Copyright (c) 2013 International Association for the Study of Pain. Published by 
      Elsevier B.V. All rights reserved.
FAU - Oono, Yuka
AU  - Oono Y
AD  - Center for Sensory-Motor Interaction (SMI), Department of Health Science and 
      Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark Section of 
      Anesthesiology and Clinical Physiology, Department of Oral Restitution, Graduate 
      School of Medical and Dental Sciences, Tokyo Medical and Dental University, 
      Tokyo, Japan Section of Clinical Oral Physiology, Department of Dentistry, Aarhus 
      University, Aarhus, Denmark Department of Oral & Maxillofacial Surgery, Aalborg 
      Hospital, Aalborg, Denmark Center of Functionally Integrative Neuroscience 
      (CFIN), MindLab, Aarhus University Hospital, Aarhus, Denmark.
FAU - Baad-Hansen, Lene
AU  - Baad-Hansen L
FAU - Wang, Kelun
AU  - Wang K
FAU - Arendt-Nielsen, Lars
AU  - Arendt-Nielsen L
FAU - Svensson, Peter
AU  - Svensson P
LA  - eng
GR  - K12-DE14069/DE/NIDCR NIH HHS/United States
GR  - R21-DE018768/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130801
PL  - United States
TA  - Pain
JT  - Pain
JID - 7508686
SB  - IM
MH  - Adult
MH  - Conditioning, Psychological/*physiology
MH  - Evoked Potentials, Somatosensory/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain/diagnosis/*physiopathology
MH  - Pain Management/*methods/psychology
MH  - Pain Measurement/*methods
MH  - Pain Threshold/physiology/psychology
MH  - Pressure/adverse effects
MH  - Treatment Outcome
MH  - Trigeminal Nerve/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Conditioned pain modulation
OT  - Diffuse noxious inhibitory controls
OT  - Experimental pain in humans
OT  - Pain modulation
OT  - Quantitative sensory testing
OT  - Trigeminal pain physiology
EDAT- 2013/08/06 06:00
MHDA- 2014/07/06 06:00
CRDT- 2013/08/06 06:00
PHST- 2013/02/10 00:00 [received]
PHST- 2013/07/23 00:00 [revised]
PHST- 2013/07/26 00:00 [accepted]
PHST- 2013/08/06 06:00 [entrez]
PHST- 2013/08/06 06:00 [pubmed]
PHST- 2014/07/06 06:00 [medline]
AID - 00006396-201312000-00017 [pii]
AID - 10.1016/j.pain.2013.07.049 [doi]
PST - ppublish
SO  - Pain. 2013 Dec;154(12):2684-2690. doi: 10.1016/j.pain.2013.07.049. Epub 2013 Aug 
      1.