PMID- 23911794
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20171225
IS  - 1095-9327 (Electronic)
IS  - 1044-7431 (Linking)
VI  - 56
DP  - 2013 Sep
TI  - Regular treadmill exercise prevents sleep deprivation-induced disruption of 
      synaptic plasticity and associated signaling cascade in the dentate gyrus.
PG  - 375-83
LID - S1044-7431(13)00077-8 [pii]
LID - 10.1016/j.mcn.2013.07.011 [doi]
AB  - STUDY OBJECTIVES: Evidence suggests that regular exercise can protect against 
      learning and memory impairment in the presence of insults such as sleep 
      deprivation. The dentate gyrus (DG) area of the hippocampus is a key staging area 
      for learning and memory processes and is particularly sensitive to sleep 
      deprivation. The purpose of this study was to determine the effect of regular 
      exercise on early-phase long-term potentiation (E-LTP) and its signaling cascade 
      in the presence of sleep deprivation. EXPERIMENTAL DESIGN: Rats were exposed to 4 
      weeks of regular treadmill exercise then subsequently sleep-deprived for 24h 
      using the modified multiple platform model before experimentation. We tested the 
      effects of exercise and/or sleep deprivation using electrophysiological recording 
      in the DG to measure synaptic plasticity; and Western blot analysis to quantify 
      the levels of key signaling proteins related to E-LTP. MEASUREMENTS AND RESULTS: 
      Regular exercise prevented the sleep deprivation-induced impairment of E-LTP in 
      the DG area as well as the sleep deprivation-associated decrease in basal protein 
      levels of phosphorylated and total alpha calcium/calmodulin-dependent protein kinase 
      II (P/total-CaMKII) and brain-derived neurotrophic factor (BDNF). High frequency 
      stimulation (HFS) to the DG area was used to model learning stimuli and increased 
      the P-CaMKII and BDNF levels in normal animals: yet failed to change these levels 
      in sleep-deprived rats. However, HFS in control and sleep-deprived rats increased 
      the levels of the phosphatase calcineurin. In contrast, exercise increased BDNF 
      and P-CaMKII levels in exercised/sleep-deprived rats. CONCLUSIONS: Regular 
      exercise appears to exert a protective effect against sleep deprivation-induced 
      spatial memory impairment by inducing hippocampal signaling cascades that 
      positively modulate basal and stimulated levels of key effectors such as P-CaMKII 
      and BDNF, while attenuating increases in the protein phosphatase calcineurin.
CI  - (c) 2013.
FAU - Zagaar, Munder
AU  - Zagaar M
AD  - Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 
      TX, USA.
FAU - Dao, An
AU  - Dao A
FAU - Alhaider, Ibrahim
AU  - Alhaider I
FAU - Alkadhi, Karim
AU  - Alkadhi K
LA  - eng
GR  - R15 103327/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130730
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
SB  - IM
EIN - Mol Cell Neurosci. 2017 Dec 22;:. PMID: 29276073
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics/metabolism
MH  - Dentate Gyrus/metabolism/*physiopathology
MH  - *Long-Term Potentiation
MH  - Male
MH  - *Physical Exertion
MH  - Rats
MH  - Rats, Wistar
MH  - Signal Transduction
MH  - Sleep Deprivation/metabolism/*physiopathology
OTO - NOTNLM
OT  - BDNF
OT  - CaMKII
OT  - Calcineurin
OT  - Forced exercise
OT  - LTP
OT  - Sleep deprivation
EDAT- 2013/08/06 06:00
MHDA- 2014/06/21 06:00
CRDT- 2013/08/06 06:00
PHST- 2013/04/23 00:00 [received]
PHST- 2013/07/05 00:00 [revised]
PHST- 2013/07/24 00:00 [accepted]
PHST- 2013/08/06 06:00 [entrez]
PHST- 2013/08/06 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
AID - S1044-7431(13)00077-8 [pii]
AID - 10.1016/j.mcn.2013.07.011 [doi]
PST - ppublish
SO  - Mol Cell Neurosci. 2013 Sep;56:375-83. doi: 10.1016/j.mcn.2013.07.011. Epub 2013 
      Jul 30.