PMID- 23912570
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211021
IS  - 1537-1603 (Electronic)
IS  - 0736-0258 (Print)
IS  - 0736-0258 (Linking)
VI  - 30
IP  - 4
DP  - 2013 Aug
TI  - Spectrum of nonconvulsive status epilepticus in patients with cancer.
PG  - 339-43
LID - 10.1097/WNP.0b013e31829ddcdb [doi]
AB  - PURPOSE: Determine incidence, clinical presentation, electrographic correlates, 
      and outcome of nonconvulsive status epilepticus (NCSE) in cancer patients on whom 
      an EEG was performed. METHODS: Retrospective review of 947 EEG reports on 658 
      patients in whom any type of EEG was performed at Memorial Sloan-Kettering Cancer 
      Center (July 2006 to March 2008). Using the Epilepsy Research Foundation 
      criteria, patients were classified as definite or probable NCSE. Medical records 
      were reviewed for diagnosis, causes of NCSE, response to treatment, and outcome. 
      Mortality was determined for patients with NCSE. RESULTS: Twenty-six episodes of 
      NCSE were identified in 25 patients (25/658, 4%). Eleven patients had primary 
      brain tumor, 12 patients systemic cancer, and two had both. At diagnostic EEG, 18 
      were awake, 3 were lethargic, and 5 patients were comatose. EEG revealed a 
      seizure in 62% of the patients, periodic lateralized epileptiform discharges in 
      42%, and periodic epileptiform discharges in 7.7%. Neuroimaging revealed new 
      intracranial pathology in 54% of the patients. Seventy-seven percent of the 
      patients achieved control; 65% required >/=3 antiepileptic drugs, and 33% required 
      intubation. Three patients died from NCSE. DISCUSSION: In our cohort, awake NCSE 
      was more common than comatose NCSE. Treatment was successful in patients with 
      heterogeneous central nervous system disease. EEG evaluation should be considered 
      in patients with cancer because NCSE is treatable despite a high prevalence of 
      structural brain disease. Nonconvulsive status epilepticus control did not always 
      require intubation and burst suppression, but frequently required three or more 
      antiepileptic drugs.
FAU - Spindler, Meredith
AU  - Spindler M
AD  - Department of Neurology and Neuroscience, Weill Medical College of Cornell 
      University, New York, NY, USA.
FAU - Jacks, Lindsay M
AU  - Jacks LM
FAU - Chen, Xi
AU  - Chen X
FAU - Panageas, Katherine
AU  - Panageas K
FAU - DeAngelis, Lisa M
AU  - DeAngelis LM
FAU - Avila, Edward K
AU  - Avila EK
LA  - eng
GR  - P30 CA008748/CA/NCI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Clin Neurophysiol
JT  - Journal of clinical neurophysiology : official publication of the American 
      Electroencephalographic Society
JID - 8506708
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anticonvulsants/therapeutic use
MH  - Brain/drug effects/pathology/*physiopathology
MH  - Brain Neoplasms/epidemiology/secondary
MH  - Child
MH  - Child, Preschool
MH  - Coma/physiopathology
MH  - Electroencephalography/instrumentation/*methods
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Lethargy/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis/pathology
MH  - Neoplasms/*epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Seizures/drug therapy/*physiopathology
MH  - Status Epilepticus/drug therapy/*epidemiology/mortality
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC5426560
MID - NIHMS864059
EDAT- 2013/08/06 06:00
MHDA- 2013/12/16 06:00
PMCR- 2017/05/11
CRDT- 2013/08/06 06:00
PHST- 2013/08/06 06:00 [entrez]
PHST- 2013/08/06 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2017/05/11 00:00 [pmc-release]
AID - 00004691-201308000-00003 [pii]
AID - 10.1097/WNP.0b013e31829ddcdb [doi]
PST - ppublish
SO  - J Clin Neurophysiol. 2013 Aug;30(4):339-43. doi: 10.1097/WNP.0b013e31829ddcdb.