PMID- 23912806
OWN - NLM
STAT- MEDLINE
DCOM- 20140625
LR  - 20220316
IS  - 1179-2035 (Electronic)
IS  - 0112-1642 (Linking)
VI  - 43
IP  - 11
DP  - 2013 Nov
TI  - Effects of exercise training on arterial function in type 2 diabetes mellitus: a 
      systematic review and meta-analysis.
PG  - 1191-9
LID - 10.1007/s40279-013-0085-2 [doi]
AB  - BACKGROUND AND OBJECTIVE: Controversy exists among trials assessing whether 
      exercise can improve arterial function in type 2 diabetes mellitus (T2DM) 
      subjects. Therefore the aim of this study was to systematically review and 
      quantify the effects of exercise on arterial function in T2DM subjects. METHODS: 
      MEDLINE, Cochrane, Scopus and Web of Science were searched up until January 2013 
      for randomized controlled trials evaluating the effects of exercise interventions 
      lasting 4 weeks or more on arterial function in T2DM subjects. Flow-mediated 
      dilation (FMD) and nitrate-mediated dilation (NMD) of the brachial conduit artery 
      were considered for assessment of arterial endothelial function and smooth muscle 
      function, respectively. RESULTS: Five randomized trials comparing exercise and 
      control groups (overall n = 217) met the inclusion criteria. The mean exercise 
      characteristics were as follows: 3.6 sessions per week, 67.5 min per session, 
      intensity at 74.4 % of the maximum heart rate (HR(max)), for 14 weeks. The 
      post-intervention mean difference in FMD favoured the exercise groups over the 
      control groups (2.23 %; P < 0.0001). No significant post-intervention mean 
      difference in NMD (1.22 %; P = 0.29) was found between the groups. Neither 
      heterogeneity nor publication bias was detected among the trials. CONCLUSION: 
      Exercise training alone improved FMD, showing its capacity to restore arterial 
      endothelial function in T2DM subjects. However, further research is needed to 
      determine whether longer and/or more intense exercise interventions could enhance 
      arterial smooth muscle function in this population.
FAU - Montero, David
AU  - Montero D
AD  - Avignon University, LAPEC EA4278, 84000, Avignon, France, 
      david.montero.barril@gmail.com.
FAU - Walther, Guillaume
AU  - Walther G
FAU - Benamo, Eric
AU  - Benamo E
FAU - Perez-Martin, Antonia
AU  - Perez-Martin A
FAU - Vinet, Agnes
AU  - Vinet A
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - New Zealand
TA  - Sports Med
JT  - Sports medicine (Auckland, N.Z.)
JID - 8412297
RN  - 0 (Nitric Oxide Donors)
SB  - IM
MH  - Arteries/*physiopathology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Endothelium/physiopathology
MH  - Exercise/*physiology
MH  - Humans
MH  - Muscle, Smooth, Vascular/drug effects/physiopathology
MH  - Nitric Oxide Donors/pharmacology
MH  - *Vasodilation/drug effects/physiology
EDAT- 2013/08/06 06:00
MHDA- 2014/06/26 06:00
CRDT- 2013/08/06 06:00
PHST- 2013/08/06 06:00 [entrez]
PHST- 2013/08/06 06:00 [pubmed]
PHST- 2014/06/26 06:00 [medline]
AID - 10.1007/s40279-013-0085-2 [doi]
PST - ppublish
SO  - Sports Med. 2013 Nov;43(11):1191-9. doi: 10.1007/s40279-013-0085-2.