PMID- 23912918
OWN - NLM
STAT- MEDLINE
DCOM- 20140401
LR  - 20180815
IS  - 2241-5955 (Electronic)
IS  - 1109-9666 (Linking)
VI  - 54
IP  - 4
DP  - 2013 Jul-Aug
TI  - Apical rotation as an early indicator of left ventricular systolic dysfunction in 
      acute anterior myocardial infarction: experimental study.
PG  - 264-72
AB  - INTRODUCTION: The aim of this study was to determine whether left ventricular 
      (LV) apical rotation assessed by speckle tracking echocardiography (STE) can 
      predict global LV systolic dysfunction after acute anterior myocardial infarction 
      (AMI). METHODS: STE analysis was applied to LV short-axis images at the basal and 
      apical levels in 21 open-chest pigs, before and after left anterior descending 
      coronary artery ligation. LV radial and circumferential strain and strain rate, 
      apical and basal rotation, and LV torsion were recorded. RESULTS: LV apical 
      rotation (3.68 +/- 1.73 degrees  pre-AMI vs. 2.19 +/- 1.64 degrees  post-AMI, p<0.009), peak systolic 
      rotation rate, and radial and circumferential strain as well as strain rate 
      decreased significantly 30 min postAMI. The LV global torsion decreased 
      significantly. Strain and rotational changes of the LV apex were primarily 
      correlated with ejection fraction (EF), but those of the LV base were not. EF had 
      a significant correlation with the global LV twist (r=0.31, p<0.05). On 
      multivariate linear regression analysis, fractional shortening of the long-axis 
      (FSL) (b=0.58, p<0.001), rotation of the LV apex (b=0.32, p<0.006) and LV 
      dp/dtmax (b=0.26, p<0.02) were independently related with EF. On analysis, of the 
      receiver operating characteristic curve, the area under the curve for apical 
      rotation was 0.765, p<0.006; the best cutoff value of 2.92 degrees  had sensitivity 80% 
      and specificity 71% in predicting EF<40%. CONCLUSION: Apical rotation assessed by 
      STE is a potential noninvasive early indicator of global LV systolic dysfunction 
      in AMI and has a satisfactory association with LVEF. Its assessment could be 
      valuable in clinical and research cardiology.
FAU - Toumanidis, Savvas T
AU  - Toumanidis ST
AD  - Department of Clinical Therapeutics, Medical School, National and Kapodistrian 
      University of Athens, Alexandra Hospital, Athens, Greece. stouman@otenet.gr
FAU - Kaladaridou, Anna
AU  - Kaladaridou A
FAU - Bramos, Dimitrios
AU  - Bramos D
FAU - Skaltsiotes, Elias
AU  - Skaltsiotes E
FAU - Agrios, John N
AU  - Agrios JN
FAU - Vasiladiotis, Nikolaos
AU  - Vasiladiotis N
FAU - Pamboucas, Constantinos
AU  - Pamboucas C
FAU - Kottis, George
AU  - Kottis G
FAU - Moulopoulos, Spyridon D
AU  - Moulopoulos SD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Hellenic J Cardiol
JT  - Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese
JID - 101257381
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - *Early Diagnosis
MH  - Echocardiography, Doppler/*methods
MH  - Heart Ventricles/*diagnostic imaging/physiopathology
MH  - Myocardial Infarction/*complications/physiopathology
MH  - Prognosis
MH  - Stroke
MH  - Swine
MH  - Systole
MH  - Ventricular Dysfunction, Left/*diagnosis/etiology/physiopathology
MH  - Ventricular Function/*physiology
EDAT- 2013/08/06 06:00
MHDA- 2014/04/02 06:00
CRDT- 2013/08/06 06:00
PHST- 2013/08/06 06:00 [entrez]
PHST- 2013/08/06 06:00 [pubmed]
PHST- 2014/04/02 06:00 [medline]
PST - ppublish
SO  - Hellenic J Cardiol. 2013 Jul-Aug;54(4):264-72.