PMID- 23913471
OWN - NLM
STAT- MEDLINE
DCOM- 20150115
LR  - 20161125
IS  - 1099-0844 (Electronic)
IS  - 0263-6484 (Linking)
VI  - 32
IP  - 2
DP  - 2014 Mar
TI  - Alterations in circulating angiogenic and anti-angiogenic factors in type 2 
      diabetic patients with neuropathy.
PG  - 155-63
LID - 10.1002/cbf.2987 [doi]
AB  - Diabetic peripheral neuropathy (DPN) is one of the most common diabetic chronic 
      complications. There is an increased attention directed towards the role of 
      angiogenic factors including vascular endothelial growth factor (VEGF) and 
      anti-angiogenic factors including soluble endoglin (sEng) as contributors to 
      diabetic microvascular complications including neuropathy. The purposes of this 
      study were to determine the role of these angiogenesis regulators in the 
      prognosis of DPN. The study group included 60 patients with type 2 diabetes 
      mellitus (T2DM) and 20 clinically healthy individuals. The patients were divided 
      into two groups. Group I included 20 T2DM patients without peripheral neuropathy, 
      and Group II consisted of 40 T2DM patients with DPN. In all groups, plasma VEGF, 
      sEng and endothelin-1 (ET-1), nitric oxide and ET-1 mRNA were estimated. Plasma 
      levels of VEGF, sEng, ET-1 and nitric oxide were significantly elevated in 
      diabetic patients (Groups I and II) compared with healthy control subjects, with 
      a higher increase in their levels in patients with DPN compared with diabetic 
      patients without peripheral neuropathy. Measurement of plasma levels of 
      angiogenesis-related biomarkers in high-risk diabetic patients might identify who 
      later develop DPN, thus providing opportunities for early detection and targets 
      for novel treatments.
CI  - Copyright (c) 2013 John Wiley & Sons, Ltd.
FAU - Motawi, Tarek Kamal
AU  - Motawi TK
AD  - Faculty of Pharmacy, Cairo University, Biochemistry, Cairo, Egypt.
FAU - Rizk, Sherine Maher
AU  - Rizk SM
FAU - Ibrahim, Ihab Abdel-Rahman
AU  - Ibrahim IA
FAU - El-Emady, Yasmin Farid
AU  - El-Emady YF
LA  - eng
PT  - Journal Article
DEP - 20130703
PL  - England
TA  - Cell Biochem Funct
JT  - Cell biochemistry and function
JID - 8305874
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers)
RN  - 0 (ENG protein, human)
RN  - 0 (Endoglin)
RN  - 0 (Endothelin-1)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, CD/blood
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Diabetic Neuropathies/*blood/etiology
MH  - Endoglin
MH  - Endothelin-1/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Neovascularization, Physiologic
MH  - Nitric Oxide/blood
MH  - RNA, Messenger/blood
MH  - Receptors, Cell Surface/blood
MH  - Vascular Endothelial Growth Factor A/blood
OTO - NOTNLM
OT  - diabetic peripheral neuropathy
OT  - endothelin-1
OT  - endothelin-1 mRNA
OT  - nitric oxide
OT  - soluble endoglin
OT  - vascular endothelial growth factor
EDAT- 2013/08/06 06:00
MHDA- 2015/01/16 06:00
CRDT- 2013/08/06 06:00
PHST- 2013/04/16 00:00 [received]
PHST- 2013/05/20 00:00 [revised]
PHST- 2013/06/04 00:00 [accepted]
PHST- 2013/08/06 06:00 [entrez]
PHST- 2013/08/06 06:00 [pubmed]
PHST- 2015/01/16 06:00 [medline]
AID - 10.1002/cbf.2987 [doi]
PST - ppublish
SO  - Cell Biochem Funct. 2014 Mar;32(2):155-63. doi: 10.1002/cbf.2987. Epub 2013 Jul 
      3.