PMID- 23913582
OWN - NLM
STAT- MEDLINE
DCOM- 20150727
LR  - 20181202
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 30
IP  - 2
DP  - 2015 Feb
TI  - Effects of environmental organochlorine pesticides on human breast cancer: 
      putative involvement on invasive cell ability.
PG  - 168-76
LID - 10.1002/tox.21882 [doi]
AB  - Human exposure to persistent organic pollutants (POPs) is a certainty, even to 
      long banned pesticides like o,p'-dichlorodiphenyltrichloroethane (o,p'-DDT), and 
      its metabolites p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), and 
      p,p'-dichlorodiphenyldichloroethane (p,p'-DDD). POPs are known to be particularly 
      toxic and have been associated with endocrine-disrupting effects in several 
      mammals, including humans even at very low doses. As environmental estrogens, 
      they could play a critical role in carcinogenesis, such as in breast cancer. With 
      the purpose of evaluating their effect on breast cancer biology, o,p'-DDT, 
      p,p'-DDE, and p,p'-DDD (50-1000 nM) were tested on two human breast 
      adenocarcinoma cell lines: MCF-7 expressing estrogen receptor (ER) alpha and 
      MDA-MB-231 negative for ERalpha, regarding cell proliferation and viability in 
      addition to their invasive potential. Cell proliferation and viability were not 
      equally affected by these compounds. In MCF-7 cells, the compounds were able to 
      decrease cell proliferation and viability. On the other hand, no evident response 
      was observed in treated MDA-MB-231 cells. Concerning the invasive potential, the 
      less invasive cell line, MCF-7, had its invasion potential significantly induced, 
      while the more invasive cell line MDA-MB-231, had its invasion potential 
      dramatically reduced in the presence of the tested compounds. Altogether, the 
      results showed that these compounds were able to modulate several cancer-related 
      processes, namely in breast cancer cell lines, and underline the relevance of POP 
      exposure to the risk of cancer development and progression, unraveling distinct 
      pathways of action of these compounds on tumor cell biology.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Pestana, Diogo
AU  - Pestana D
AD  - Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 
      Centro de Investigacao Medica, Rua Dr. Placido da Costa, Porto, Portugal.
FAU - Teixeira, Diana
AU  - Teixeira D
FAU - Faria, Ana
AU  - Faria A
FAU - Domingues, Valentina
AU  - Domingues V
FAU - Monteiro, Rosario
AU  - Monteiro R
FAU - Calhau, Conceicao
AU  - Calhau C
LA  - eng
PT  - Journal Article
DEP - 20130802
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 9007-49-2 (DNA)
RN  - 958-74-7 (methylthymidine)
RN  - CIW5S16655 (DDT)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - Breast Neoplasms/*chemically induced/*pathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - DDT/analogs & derivatives/toxicity
MH  - DNA/biosynthesis/genetics
MH  - Endocrine Disruptors/toxicity
MH  - Environmental Pollutants/*toxicity
MH  - Estrogen Receptor alpha/drug effects
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*toxicity
MH  - MCF-7 Cells
MH  - Neoplasm Invasiveness/pathology
MH  - Pesticides/*toxicity
MH  - Thymidine/analogs & derivatives/metabolism
OTO - NOTNLM
OT  - breast cancer
OT  - dichlorodiphenyltrichloroethane
OT  - endocrine disruptors
OT  - invasion
OT  - persistent organic pollutants, organochlorine pesticides
EDAT- 2013/08/06 06:00
MHDA- 2015/07/28 06:00
CRDT- 2013/08/06 06:00
PHST- 2012/11/13 00:00 [received]
PHST- 2013/05/21 00:00 [revised]
PHST- 2013/05/22 00:00 [accepted]
PHST- 2013/08/06 06:00 [entrez]
PHST- 2013/08/06 06:00 [pubmed]
PHST- 2015/07/28 06:00 [medline]
AID - 10.1002/tox.21882 [doi]
PST - ppublish
SO  - Environ Toxicol. 2015 Feb;30(2):168-76. doi: 10.1002/tox.21882. Epub 2013 Aug 2.