PMID- 23913758
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20140813
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 36
IP  - 9
DP  - 2014 Sep
TI  - Fibroblast growth factor receptor-1 as a potential therapeutic target in 
      sinonasal cancer.
PG  - 1253-7
LID - 10.1002/hed.23443 [doi]
AB  - BACKGROUND: Despite multimodal treatment, sinonasal malignancies have an 
      unfavorable prognosis. The purpose of this study was to elucidate if these tumors 
      harbor amplifications of the fibroblast growth factor receptor 1 (FGFR1) gene, 
      which has recently been identified as a potential therapeutic target in squamous 
      cell lung cancer. METHODS: One hundred twelve primary tumors (including squamous 
      cell carcinoma [SCC], carcinoma associated with an inverted papilloma, sinonasal 
      undifferentiated carcinoma [SNUC], adenocarcinoma, adenoid cystic carcinoma 
      [ACC], esthesioneuroblastoma, and 9 corresponding lymph node metastases) were 
      assessed by fluorescence in situ hybridization (FISH) for FGFR1 copy number 
      status. Human papillomavirus (HPV) status was assessed by p16 immunohistochemical 
      as a surrogate marker. RESULTS: FGFR1 amplification was found in subsets of 
      sinonasal SCCs (20%), carcinomas associated with an inverted papilloma (33%), and 
      SNUCs (5%). In all cases, metastatic tumor samples shared the same FGFR1 
      amplification status as the corresponding primary tumor tissue. None of the 
      FGFR1-amplified tumors expressed p16. CONCLUSION: FGFR1 amplification represents 
      a potential molecular target in a subset of patients with sinonasal cancer. (c) 
      2014 Wiley Periodicals, Inc. Head Neck 36: 1253-1257, 2014.
CI  - Copyright (c) 2014 Wiley Periodicals, Inc.
FAU - Schrock, Andreas
AU  - Schrock A
AD  - Department of Otorhinolaryngology / Head and Neck Surgery, University of Bonn, 
      Germany; Department of Prostate Cancer Research, University of Bonn, Bonn, 
      Germany.
FAU - Goke, Friederike
AU  - Goke F
FAU - Wagner, Patrick
AU  - Wagner P
FAU - Bode, Maike
AU  - Bode M
FAU - Franzen, Alina
AU  - Franzen A
FAU - Huss, Sebastian
AU  - Huss S
FAU - Agaimy, Abbas
AU  - Agaimy A
FAU - Ihrler, Stephan
AU  - Ihrler S
FAU - Kirsten, Robert
AU  - Kirsten R
FAU - Kristiansen, Glen
AU  - Kristiansen G
FAU - Bootz, Friedrich
AU  - Bootz F
FAU - Lengerke, Claudia
AU  - Lengerke C
FAU - Perner, Sven
AU  - Perner S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140201
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 1)
SB  - IM
MH  - Adenocarcinoma/*genetics/pathology/therapy
MH  - Aged
MH  - Carcinoma, Squamous Cell/*genetics/pathology/therapy
MH  - Cohort Studies
MH  - Esthesioneuroblastoma, Olfactory/*genetics/pathology/therapy
MH  - Female
MH  - Gene Amplification/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Papilloma, Inverted/*genetics/pathology/therapy
MH  - Paranasal Sinus Neoplasms/*genetics/pathology/therapy
MH  - Receptor, Fibroblast Growth Factor, Type 1/*genetics
OTO - NOTNLM
OT  - amplification
OT  - cancer
OT  - fibroblast growth factor receptor 1 (FGFR1)
OT  - sinonasal
OT  - therapy
EDAT- 2013/08/06 06:00
MHDA- 2015/05/13 06:00
CRDT- 2013/08/06 06:00
PHST- 2012/11/29 00:00 [received]
PHST- 2013/04/18 00:00 [revised]
PHST- 2013/07/25 00:00 [accepted]
PHST- 2013/08/06 06:00 [entrez]
PHST- 2013/08/06 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
AID - 10.1002/hed.23443 [doi]
PST - ppublish
SO  - Head Neck. 2014 Sep;36(9):1253-7. doi: 10.1002/hed.23443. Epub 2014 Feb 1.