PMID- 23913789
OWN - NLM
STAT- MEDLINE
DCOM- 20140527
LR  - 20130925
IS  - 1460-2229 (Electronic)
IS  - 0263-2136 (Linking)
VI  - 30
IP  - 5
DP  - 2013 Oct
TI  - Mortality in depressed and non-depressed primary care Swedish patients: a 12-year 
      follow-up cohort study.
PG  - 514-9
LID - 10.1093/fampra/cmt039 [doi]
AB  - BACKGROUND: Data regarding mortality among depressed patients in Swedish primary 
      care is limited. OBJECTIVES: We compared mortality in a cohort of depressed and 
      non-depressed patients at long-term follow-up and compared these values with 
      standardized mortality rates (SMRs) in the Swedish population. Hazards ratios 
      (HRs) for the relationship between death and depression, psychosocial factors and 
      lifestyle were analysed, and we explored the proportion of unnatural causes of 
      deaths. METHODS: Mortality was studied in a cohort of 124 depressed and 280 
      non-depressed patients 12 years after being diagnosed with depression in primary 
      care. Mortality and the mortality rates and SMRs in depressed and non-depressed 
      patients were compared by gender. Cox regression was applied to calculate HRs for 
      the risk of dying for explanatory variables, including depression, psychosocial 
      factors and lifestyle. RESULTS: A larger number of depressed patients, 11% (n = 
      14), compared with non-depressed patients, 4% (n = 12), died (P = 0.008), with 
      significantly higher values among depressed men (P = 0.014). SMRs did not differ 
      from those of the Swedish population. Depression was the only variable associated 
      with a significantly elevated risk of death (HR, 3.34; 95% CI, 1.38-8.08). Nearly 
      one-third of deaths had unnatural causes when alcohol-related deaths were 
      included. CONCLUSION: This study underlines the importance of careful follow-up 
      of all depressed patients' mental and physical health and the intervention on 
      unhealthy lifestyles. Large primary care database studies are needed to explore 
      the association between depression, co-morbid somatic diseases, lifestyle and 
      mortality.
FAU - Stromberg, Ranja
AU  - Stromberg R
AD  - Department of Neurobiology, Centre for Family Medicine, Karolinska Institutet, 
      Huddinge.
FAU - Backlund, Lars G
AU  - Backlund LG
FAU - Johansson, Sven-Erik
AU  - Johansson SE
FAU - Lofvander, Monica
AU  - Lofvander M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130802
PL  - England
TA  - Fam Pract
JT  - Family practice
JID - 8500875
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cause of Death
MH  - Depression/*mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Life Style
MH  - Male
MH  - Middle Aged
MH  - Primary Health Care/*statistics & numerical data
MH  - Proportional Hazards Models
MH  - Sex Factors
MH  - Sweden/epidemiology
OTO - NOTNLM
OT  - Depression
OT  - follow-up studies
OT  - mortality determinants
OT  - primary care
OT  - suicide.
EDAT- 2013/08/06 06:00
MHDA- 2014/05/28 06:00
CRDT- 2013/08/06 06:00
PHST- 2013/08/06 06:00 [entrez]
PHST- 2013/08/06 06:00 [pubmed]
PHST- 2014/05/28 06:00 [medline]
AID - cmt039 [pii]
AID - 10.1093/fampra/cmt039 [doi]
PST - ppublish
SO  - Fam Pract. 2013 Oct;30(5):514-9. doi: 10.1093/fampra/cmt039. Epub 2013 Aug 2.