PMID- 23915108
OWN - NLM
STAT- MEDLINE
DCOM- 20140401
LR  - 20130827
IS  - 1029-2330 (Electronic)
IS  - 1026-7158 (Linking)
VI  - 21
IP  - 8
DP  - 2013 Sep
TI  - Physicochemical, pharmaceutical and biological approaches toward designing 
      optimized and efficient hydrophobically modified chitosan-based polymeric 
      micelles as a nanocarrier system for targeted delivery of anticancer drugs.
PG  - 693-709
LID - 10.3109/1061186X.2013.824455 [doi]
AB  - Hydrophobically modified chitosan-based polymeric micelles (CBPMs) are formed 
      through self-aggregation of chitosan amphiphilic derivatives. Their core-shell 
      structure, diversity and the fact that all of their properties are adjustable 
      through reconciling the interactions among their three main constituents: 
      chitosan, hydrophilic segment and hydrophobic segment as well as with the outside 
      medium through changing the ratio and chemical structure of each component's, 
      chemical structure distinguish them from other chitosan-based drug delivery 
      systems (DDSs) and give rise to these promising candidates for targeted delivery 
      of lipophilic anticancer drugs. The majority of review articles conducted 
      previously on chitosan-based DDSs have only made simple differential comparisons 
      between such systems and the anticancer drugs that have been delivered through 
      them. In this review article, all the basic properties of CBPMs including 
      physicochemical, pharmaceutical and biological properties are technically 
      detailed and discussed. The intention of this article is to outline and discuss 
      salient features of CBPMs to contribute to the understanding of optimized 
      strategies for the design of stable and efficient CBPMs.
FAU - Mahmoudzadeh, Mohammad
AU  - Mahmoudzadeh M
AD  - Department of Pharmaceutics, Isfahan University of Medical Sciences, Isfahan, 
      Iran.
FAU - Fassihi, Afshin
AU  - Fassihi A
FAU - Emami, Jaber
AU  - Emami J
FAU - Davies, Neal M
AU  - Davies NM
FAU - Dorkoosh, Farid
AU  - Dorkoosh F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130805
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Micelles)
RN  - 0 (Polymers)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/administration & dosage/*chemistry
MH  - Chitosan/administration & dosage/*chemistry
MH  - Drug Carriers/administration & dosage/*chemistry
MH  - Drug Delivery Systems/*methods
MH  - Humans
MH  - Hydrophobic and Hydrophilic Interactions
MH  - *Micelles
MH  - Nanoparticles
MH  - Polymers/administration & dosage/*chemistry
EDAT- 2013/08/07 06:00
MHDA- 2014/04/02 06:00
CRDT- 2013/08/07 06:00
PHST- 2013/08/07 06:00 [entrez]
PHST- 2013/08/07 06:00 [pubmed]
PHST- 2014/04/02 06:00 [medline]
AID - 10.3109/1061186X.2013.824455 [doi]
PST - ppublish
SO  - J Drug Target. 2013 Sep;21(8):693-709. doi: 10.3109/1061186X.2013.824455. Epub 
      2013 Aug 5.