PMID- 23915851 OWN - NLM STAT- MEDLINE DCOM- 20140318 LR - 20221207 IS - 1875-6263 (Electronic) IS - 1028-4559 (Linking) VI - 52 IP - 2 DP - 2013 Jun TI - Association between single nucleotide polymorphisms of the estrogen receptor 1 and receptor activator of nuclear factor kappa B ligand genes and bone mineral density in postmenopausal Taiwanese. PG - 197-203 LID - S1028-4559(13)00064-8 [pii] LID - 10.1016/j.tjog.2013.04.008 [doi] AB - OBJECTIVE: To investigate the relationship between single nucleotide polymorphisms (SNPs) of the genes encoding the estrogen receptor 1 (ESR1) and the receptor activator of nuclear factor kappa B ligand (RANKL) and bone mineral density (BMD) in postmenopausal Taiwanese. MATERIALS AND METHODS: Five ESR1 SNPs and three RANKL SNPs in 467 women were genotyped. Results of genotyping were correlated with BMD that had been adjusted for body mass index (BMI), age, and years after menopause. RESULTS: Those with the ESR1 Crs1884054 allele were found to have a lower BMD at LS2-4/Lateral view (p = 0.005 and permutated p = 0.046), and those with the ESR1 haplotype Trs2234693-Ars922996 had a higher risk for low BMD also at LS2-4/Lat (OR = 1.8, 95% CI = 1.1-2.9). In addition, women without the RANKL haplotype Grs2148072-Crs2200287-Grs922996 had a higher risk for low BMD at LS1-4/AP (OR = 2.09, 95% CI = 1.21 approximately 3.64). Stratification analyses revealed that those with ESR1 AArs1884054 and RANKL Ars2148072 (p = 0.032) or RANKL Trs2200287 (p = 0.007) had a lower BMD at LS1-4/AP. CONCLUSION: Genotypes of these SNPs of ESR1 and RANKL may help us predict the osteoporosis risk in menopausal women. CI - Copyright (c) 2013. Published by Elsevier B.V. FAU - Cheng, Bi-Hua AU - Cheng BH AD - Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, College of Medicine, Kaohsiung, Taiwan. FAU - Wang, Tzu-Hao AU - Wang TH FAU - Kang, Hong-Yo AU - Kang HY FAU - Lin, Ying-Chu AU - Lin YC FAU - Huang, Chun-Chen AU - Huang CC FAU - Hsu, Te-Yao AU - Hsu TY FAU - Kung, Fu-Tsai AU - Kung FT FAU - Huang, Ko-En AU - Huang KE LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - China (Republic : 1949- ) TA - Taiwan J Obstet Gynecol JT - Taiwanese journal of obstetrics & gynecology JID - 101213819 RN - 0 (ESR1 protein, human) RN - 0 (Estrogen Receptor alpha) RN - 0 (RANK Ligand) RN - 0 (TNFSF11 protein, human) SB - IM MH - Asian People/*genetics/statistics & numerical data MH - Bone Density/*genetics MH - Estrogen Receptor alpha/*genetics MH - Female MH - Gene Frequency MH - Haplotypes MH - Humans MH - Linkage Disequilibrium MH - Middle Aged MH - Osteoporosis, Postmenopausal/*ethnology/*genetics MH - Polymorphism, Single Nucleotide MH - Postmenopause/genetics MH - RANK Ligand/*genetics MH - Risk Factors MH - Taiwan/epidemiology OTO - NOTNLM OT - ESR1 OT - RANKL OT - TNFSF11 OT - bone mineral density OT - single nucleotide polymorphism EDAT- 2013/08/07 06:00 MHDA- 2014/03/19 06:00 CRDT- 2013/08/07 06:00 PHST- 2012/01/11 00:00 [accepted] PHST- 2013/08/07 06:00 [entrez] PHST- 2013/08/07 06:00 [pubmed] PHST- 2014/03/19 06:00 [medline] AID - S1028-4559(13)00064-8 [pii] AID - 10.1016/j.tjog.2013.04.008 [doi] PST - ppublish SO - Taiwan J Obstet Gynecol. 2013 Jun;52(2):197-203. doi: 10.1016/j.tjog.2013.04.008.