PMID- 2391592
OWN - NLM
STAT- MEDLINE
DCOM- 19901003
LR  - 20190630
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 117
IP  - 3
DP  - 1990 Sep
TI  - Effect of formula carbohydrate concentration on tolerance and macronutrient 
      absorption in infants with severe, chronic diarrhea.
PG  - 378-83
AB  - To determine how the carbohydrate (CHO) content of "semielemental" formulas 
      affects tolerance and macronutrient absorption, we enrolled 12 infants with 
      severe diarrhea in two successive metabolic balance studies. The infants 
      received, in random order, one of two isocaloric formulas that differed mainly in 
      their CHO and fat concentrations. No significant differences were found between 
      the two feeding periods for peak breath hydrogen levels and fecal osmolality. The 
      low-CHO formula was tolerated better than the high-CHO formula, as indicated by a 
      significantly lower stool output (mean +/- SD 387 +/- 230 vs 764 +/- 443 gm, 
      respectively; p less than 0.05), and higher fecal pH (5.9 +/- 0.7 vs 4.9 +/- 0.5; 
      p less than 0.05). Macronutrient absorption was greater during the ingestion of 
      the low-CHO formula, as indicated by a significantly higher coefficient of fat 
      absorption (p less than 0.005) and lower total fecal energy (mean +/- SD for 
      high- vs low-CHO formula, 372 +/- 205 vs 207 +/- 102 kcal; p less than 0.05), 
      which resulted from a lower CHO excretion (p less than 0.05). A correlation 
      coefficient between the energy derived from CHO in feces and the total stool 
      output was significant for both the high-CHO formula (r = 0.83; p less than 
      0.001) and the low-CHO formula (r = 0.7; p = 0.01). The CHO concentration of the 
      special infant formula that we tested had an overriding effect on stool output 
      and on fat and energy absorption.
FAU - Lifschitz, C H
AU  - Lifschitz CH
AD  - U.S. Department of Agriculture/Agricultural Research Service, Children's 
      Nutrition Research Center, Houston, TX 77030.
FAU - Carrazza, F
AU  - Carrazza F
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Chronic Disease
MH  - Diarrhea, Infantile/*diet therapy/metabolism
MH  - Dietary Carbohydrates/*administration & dosage/metabolism/pharmacology
MH  - Dietary Fats/administration & dosage/metabolism
MH  - Energy Intake
MH  - Feces/analysis
MH  - Humans
MH  - Infant
MH  - Infant Food/*adverse effects
MH  - Intestinal Absorption/drug effects
MH  - Male
MH  - Random Allocation
EDAT- 1990/09/01 00:00
MHDA- 1990/09/01 00:01
CRDT- 1990/09/01 00:00
PHST- 1990/09/01 00:00 [pubmed]
PHST- 1990/09/01 00:01 [medline]
PHST- 1990/09/01 00:00 [entrez]
AID - S0022-3476(05)81076-5 [pii]
AID - 10.1016/s0022-3476(05)81076-5 [doi]
PST - ppublish
SO  - J Pediatr. 1990 Sep;117(3):378-83. doi: 10.1016/s0022-3476(05)81076-5.