PMID- 23916320 OWN - NLM STAT- MEDLINE DCOM- 20140314 LR - 20130819 IS - 1879-0046 (Electronic) IS - 0376-8716 (Linking) VI - 132 IP - 1-2 DP - 2013 Sep 1 TI - Clinical and pharmacological aspects of bath salt use: a review of the literature and case reports. PG - 1-12 LID - S0376-8716(13)00235-4 [pii] LID - 10.1016/j.drugalcdep.2013.06.016 [doi] AB - Bath salts are designer drugs with stimulant properties that are a growing medical and psychiatric concern due to their widespread availability and use. Although the chemical compounds in the mixtures referred to as "bath salts" vary, many are derivatives of cathinone, a monoamine alkaloid. Cathinones have an affinity for dopamine, serotonin, and norepinephrine synapses in the brain. Because of the strong selection for these neurotransmitters, these drugs induce stimulating effects similar to those of methamphetamines, cocaine, and 3,4-methylenedioxy-N-methylamphetamine (MDMA). Much of the emerging information about bath salts is from emergency department evaluation and treatment of severe medical and neuropsychiatric adverse outcomes. This review consists of a compilation of case reports and describes the emergent literature that illustrates the chemical composition of bath salts, patterns of use, administration methods, medical and neuropsychiatric effects, and treatments of patients with bath salt toxicity. CI - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved. FAU - Miotto, Karen AU - Miotto K AD - David Geffen School of Medicine at UCLA, Semel Institute of Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA 90095, United States. kmiotto@mednet.ucla.edu FAU - Striebel, Joan AU - Striebel J FAU - Cho, Arthur K AU - Cho AK FAU - Wang, Christine AU - Wang C LA - eng PT - Journal Article PT - Review DEP - 20130801 PL - Ireland TA - Drug Alcohol Depend JT - Drug and alcohol dependence JID - 7513587 RN - 0 (Alkaloids) RN - 0 (Central Nervous System Stimulants) RN - 0 (Designer Drugs) RN - 540EI4406J (cathinone) SB - IM MH - Adolescent MH - Adult MH - Age Factors MH - *Alkaloids/chemistry/pharmacokinetics/pharmacology/poisoning/toxicity MH - Animals MH - Brain Chemistry/drug effects MH - *Central Nervous System Stimulants/chemistry/pharmacokinetics/pharmacology/poisoning/toxicity MH - *Designer Drugs/chemistry/pharmacokinetics/pharmacology/poisoning/toxicity MH - Drug Overdose/epidemiology/mortality/psychology MH - Humans MH - Substance Withdrawal Syndrome/psychology MH - Substance-Related Disorders/epidemiology/*psychology MH - Young Adult OTO - NOTNLM OT - Bath salts OT - Cathinone OT - Hallucinations OT - Psychosis OT - Stimulant OT - Tachycardic EDAT- 2013/08/07 06:00 MHDA- 2014/03/15 06:00 CRDT- 2013/08/07 06:00 PHST- 2012/12/15 00:00 [received] PHST- 2013/04/26 00:00 [revised] PHST- 2013/06/20 00:00 [accepted] PHST- 2013/08/07 06:00 [entrez] PHST- 2013/08/07 06:00 [pubmed] PHST- 2014/03/15 06:00 [medline] AID - S0376-8716(13)00235-4 [pii] AID - 10.1016/j.drugalcdep.2013.06.016 [doi] PST - ppublish SO - Drug Alcohol Depend. 2013 Sep 1;132(1-2):1-12. doi: 10.1016/j.drugalcdep.2013.06.016. Epub 2013 Aug 1.