PMID- 23916757
OWN - NLM
STAT- MEDLINE
DCOM- 20140318
LR  - 20211203
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 253
DP  - 2013 Sep 15
TI  - Paternal treadmill exercise enhances spatial learning and memory related to 
      hippocampus among male offspring.
PG  - 297-304
LID - S0166-4328(13)00439-7 [pii]
LID - 10.1016/j.bbr.2013.07.040 [doi]
AB  - Both epidemiologic and laboratory studies suggest that parents can shape their 
      offspring's development. Recently, it has been shown that maternal exercise 
      during pregnancy benefits the progeny's brain function. However, little is known 
      regarding the influence of paternal exercise on their offspring's phenotype. In 
      this study we attempt to determine the effects of 6 weeks paternal treadmill 
      exercise on spatial learning and memory and the expression of brain-derived 
      neurotrophic factor (BDNF) and reelin in their male offspring. Sibling males were 
      divided into two groups: the control (C) and the exercise group (E). The mice in 
      the E group were exercised on a motor-driven rodent treadmill for 5 days per week 
      for 6 weeks. After 6 weeks of exercise, the male mouse was mated with its sibling 
      female. After weaning, male pups underwent behavioral assessment (Open field and 
      Morris water maze tests). Immunohistochemistry staining, real time-PCR and 
      western blot were performed to determine hippocampal BDNF and reelin expression 
      of the male pups after behavior tasks. Our results showed that paternal treadmill 
      exercise improved the spatial learning and memory capability of male pups, which 
      was accompanied by significantly increased expression of BDNF and reelin, as 
      compared to those of C group. Our results provide novel evidence that paternal 
      treadmill exercise can enhance the brain functions of their F1 male offspring.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Yin, M M
AU  - Yin MM
AD  - Department of Rehabilitation and Sports Medicine, Tianjin Medical University, 
      Tianjin, 300070, China.
FAU - Wang, W
AU  - Wang W
FAU - Sun, J
AU  - Sun J
FAU - Liu, S
AU  - Liu S
FAU - Liu, X L
AU  - Liu XL
FAU - Niu, Y M
AU  - Niu YM
FAU - Yuan, H R
AU  - Yuan HR
FAU - Yang, F Y
AU  - Yang FY
FAU - Fu, L
AU  - Fu L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130731
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Reelin Protein)
RN  - 63231-63-0 (RNA)
RN  - EC 3.4.21.- (Reln protein, mouse)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Body Weight/physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Adhesion Molecules, Neuronal/metabolism
MH  - Extracellular Matrix Proteins/metabolism
MH  - Female
MH  - Hippocampus/*physiology
MH  - Immunohistochemistry
MH  - Male
MH  - Maze Learning/*physiology
MH  - Memory/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Motor Activity/physiology
MH  - Nerve Tissue Proteins/metabolism
MH  - Physical Conditioning, Animal/*psychology
MH  - Pregnancy
MH  - RNA/biosynthesis/genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - Reelin Protein
MH  - Serine Endopeptidases/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Brain-derived neurotrophic factor
OT  - CA
OT  - CM
OT  - DG
OT  - EM
OT  - HFD
OT  - LTP
OT  - MWM
OT  - Male pup
OT  - Morris water maze
OT  - Paternal treadmill exercise
OT  - Reelin
OT  - Spatial learning and memory
OT  - brain-derived neurotrophic factor
OT  - cornus ammonis
OT  - dentate gyrus
OT  - high-fat diet
OT  - long-term potentiation
OT  - paternal exercise male pups
OT  - paternal sedentary male pups
EDAT- 2013/08/07 06:00
MHDA- 2014/03/19 06:00
CRDT- 2013/08/07 06:00
PHST- 2013/05/31 00:00 [received]
PHST- 2013/07/19 00:00 [revised]
PHST- 2013/07/23 00:00 [accepted]
PHST- 2013/08/07 06:00 [entrez]
PHST- 2013/08/07 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
AID - S0166-4328(13)00439-7 [pii]
AID - 10.1016/j.bbr.2013.07.040 [doi]
PST - ppublish
SO  - Behav Brain Res. 2013 Sep 15;253:297-304. doi: 10.1016/j.bbr.2013.07.040. Epub 
      2013 Jul 31.