PMID- 23916954
OWN - NLM
STAT- MEDLINE
DCOM- 20140528
LR  - 20181202
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1317
DP  - 2013 Nov 22
TI  - Development of novel amphiphilic magnetic molecularly imprinted polymers 
      compatible with biological fluids for solid phase extraction and physicochemical 
      behavior study.
PG  - 110-20
LID - S0021-9673(13)01135-7 [pii]
LID - 10.1016/j.chroma.2013.07.075 [doi]
AB  - In the present work, a novel amphiphilic magnetic molecularly imprinted polymer 
      (M-MIP) has been synthesized by a simple non covalent method for the loading of 
      gatifloxacin (GTFX) in polar solvent. This nanomaterial used as sorbent has been 
      applied to the solid phase extraction of GTFX in different spiked biological 
      fluids. For the first time, studies of dispersibility and solubility behaviors 
      with different solvents and water were performed to demonstrate amphiphilicity 
      and also to find the better nanomaterial obtained. Fourier transform infrared 
      (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy 
      (TEM) and X-ray (XRD) were used to characterize the nanomaterials, and Scatchard 
      plot analysis to demonstrate the binding kinetic. Results suggest that the 
      dispersibility, solubility and the adsorption in water have relationships with 
      the structure of nanomaterials prepared. The oleic acid coated on the M-MIP 
      combined with the washing process has enhanced the amphiphilicity of the 
      nanomaterials. The M-MIP2 showed better selectivity and adsorption behavior with 
      imprinted efficiency higher than (2) in water, as well as in biological fluids. 
      Moreover, no interference with constituents of blank urine and blank serum 
      samples for solid phase extraction (SPE) was observed. Moreover, loading recovery 
      was found higher than 95% with low RSD. The novel amphiphilic magnetic 
      nanomaterial prepared here as sorbent is suitable for SPE of GTFX in biological 
      fluids for therapeutic monitoring control. It could be also used as carrier in 
      drug delivery system for experimental and clinical studies.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Dramou, Pierre
AU  - Dramou P
AD  - Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 
      210009, China.
FAU - Zuo, Pengli
AU  - Zuo P
FAU - He, Hua
AU  - He H
FAU - Pham-Huy, Lien Ai
AU  - Pham-Huy LA
FAU - Zou, Wenyue
AU  - Zou W
FAU - Xiao, Deli
AU  - Xiao D
FAU - Pham-Huy, Chuong
AU  - Pham-Huy C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130724
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Fluoroquinolones)
RN  - 0 (Hexanes)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Polymers)
RN  - 059QF0KO0R (Water)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - L4618BD7KJ (Gatifloxacin)
SB  - IM
MH  - Chemical Phenomena
MH  - Fluoroquinolones/blood/urine
MH  - Gatifloxacin
MH  - Hexanes
MH  - Humans
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Magnetite Nanoparticles/*chemistry
MH  - Molecular Imprinting/*methods
MH  - Oleic Acid
MH  - Polymers
MH  - Solid Phase Extraction/*methods
MH  - Water
OTO - NOTNLM
OT  - Amphiphilic magnetic-imprinted polymers
OT  - Aqueous media
OT  - Biological fluids
OT  - Physicochemical behavior study
OT  - Solid phase extraction
EDAT- 2013/08/07 06:00
MHDA- 2014/05/29 06:00
CRDT- 2013/08/07 06:00
PHST- 2013/05/02 00:00 [received]
PHST- 2013/07/03 00:00 [revised]
PHST- 2013/07/19 00:00 [accepted]
PHST- 2013/08/07 06:00 [entrez]
PHST- 2013/08/07 06:00 [pubmed]
PHST- 2014/05/29 06:00 [medline]
AID - S0021-9673(13)01135-7 [pii]
AID - 10.1016/j.chroma.2013.07.075 [doi]
PST - ppublish
SO  - J Chromatogr A. 2013 Nov 22;1317:110-20. doi: 10.1016/j.chroma.2013.07.075. Epub 
      2013 Jul 24.