PMID- 23917506
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20211021
IS  - 1678-4170 (Electronic)
IS  - 0066-782X (Print)
IS  - 0066-782X (Linking)
VI  - 101
IP  - 1
DP  - 2013 Jul
TI  - Cardiac I123-MIBG correlates better than ejection fraction with symptoms severity 
      in systolic heart failure.
PG  - 4-8
LID - S0066-782X2013002700003 [pii]
LID - 10.5935/abc.20130111 [doi]
AB  - BACKGROUND: The association of autonomic activation, left ventricular ejection 
      fraction (LVEF) and heart failure functional class is poorly understood. 
      OBJECTIVE: Our aim was to correlate symptom severity with cardiac sympathetic 
      activity, through iodine-123-metaiodobenzylguanidine (123I-MIBG) scintigraphy and 
      with LVEF in systolic heart failure (HF) patients without previous beta-blocker 
      treatment. METHODS: Thirty-one patients with systolic HF, class I to IV of the 
      New York Heart Association (NYHA), without previous beta-blocker treatment, were 
      enrolled and submitted to 123I-MIBG scintigraphy and to radionuclide 
      ventriculography for LVEF determination. The early and delayed heart/mediastinum 
      (H/M) ratio and the washout rate (WR) were performed. RESULTS: According with 
      symptom severity, patients were divided into group A, 13 patients in NYHA class 
      I/II, and group B, 18 patients in NYHA class III/IV. Compared with group B 
      patients, group A had a significantly higher LVEF (25% +/- 12% in group B vs. 32% +/- 
      7% in group A, p = 0.04). Group B early and delayed H/M ratios were lower than 
      group A ratios (early H/M 1.49 +/- 0.15 vs. 1.64 +/- 0.14, p = 0.02; delayed H/M 1.39 
      +/- 0.13 vs. 1.58 +/- 0.16, p = 0.001, respectively). WR was significantly higher in 
      group B (36% +/- 17% vs. 30% +/- 12%, p= 0.04). The variable that showed the best 
      correlation with NYHA class was the delayed H/M ratio (r= -0.585; p=0.001), 
      adjusted for age and sex. CONCLUSION: This study showed that cardiac 123I-MIBG 
      correlates better than ejection fraction with symptom severity in systolic heart 
      failure patients without previous beta-blocker treatment.
FAU - Miranda, Sandra M
AU  - Miranda SM
AD  - Programa de Pos-Graduacao em Ciencias Cardiovasculares, Hospital Universitario 
      Antonio Pedro, Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil.
FAU - Moscavitch, Samuel D
AU  - Moscavitch SD
FAU - Carestiato, Larissa R
AU  - Carestiato LR
FAU - Felix, Renata M
AU  - Felix RM
FAU - Rodrigues, Ronaldo C
AU  - Rodrigues RC
FAU - Messias, Leandro R
AU  - Messias LR
FAU - Azevedo, Jader C
AU  - Azevedo JC
FAU - Nobrega, Antonio Claudio L
AU  - Nobrega AC
FAU - Mesquita, Evandro Tinoco
AU  - Mesquita ET
FAU - Mesquita, Claudio Tinoco
AU  - Mesquita CT
LA  - eng
LA  - por
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Arq Bras Cardiol
JT  - Arquivos brasileiros de cardiologia
JID - 0421031
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Radiopharmaceuticals)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
SB  - IM
MH  - *3-Iodobenzylguanidine
MH  - Adrenergic beta-Antagonists/therapeutic use
MH  - Aged
MH  - Female
MH  - Heart Failure, Systolic/*diagnostic imaging/*physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Radionuclide Imaging
MH  - *Radiopharmaceuticals
MH  - Reference Values
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Stroke Volume/*physiology
PMC - PMC3998174
COIS- Potential Conflict of Interest: No potential conflict of interest relevant to 
      this article was reported.
EDAT- 2013/08/07 06:00
MHDA- 2014/01/28 06:00
PMCR- 2013/07/01
CRDT- 2013/08/07 06:00
PHST- 2012/06/15 00:00 [received]
PHST- 2013/01/14 00:00 [accepted]
PHST- 2013/08/07 06:00 [entrez]
PHST- 2013/08/07 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - S0066-782X2013002700003 [pii]
AID - 10.5935/abc.20130111 [doi]
PST - ppublish
SO  - Arq Bras Cardiol. 2013 Jul;101(1):4-8. doi: 10.5935/abc.20130111.