PMID- 23917628
OWN - NLM
STAT- MEDLINE
DCOM- 20131211
LR  - 20220330
IS  - 1471-0064 (Electronic)
IS  - 1471-0056 (Linking)
VI  - 14
IP  - 9
DP  - 2013 Sep
TI  - Genetic insights into common pathways and complex relationships among 
      immune-mediated diseases.
PG  - 661-73
LID - 10.1038/nrg3502 [doi]
AB  - Shared aetiopathogenic factors among immune-mediated diseases have long been 
      suggested by their co-familiality and co-occurrence, and molecular support has 
      been provided by analysis of human leukocyte antigen (HLA) haplotypes and 
      genome-wide association studies. The interrelationships can now be better 
      appreciated following the genotyping of large immune disease sample sets on a 
      shared SNP array: the 'Immunochip'. Here, we systematically analyse loci shared 
      among major immune-mediated diseases. This reveals that several diseases share 
      multiple susceptibility loci, but there are many nuances. The most associated 
      variant at a given locus frequently differs and, even when shared, the same 
      allele often has opposite associations. Interestingly, risk alleles conferring 
      the largest effect sizes are usually disease-specific. These factors help to 
      explain why early evidence of extensive 'sharing' is not always reflected in 
      epidemiological overlap.
FAU - Parkes, Miles
AU  - Parkes M
AD  - 1] Inflammatory Bowel Disease Research Group, Department of Medicine, 
      Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK. [2].
FAU - Cortes, Adrian
AU  - Cortes A
FAU - van Heel, David A
AU  - van Heel DA
FAU - Brown, Matthew A
AU  - Brown MA
LA  - eng
GR  - G1001158/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130806
PL  - England
TA  - Nat Rev Genet
JT  - Nature reviews. Genetics
JID - 100962779
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Chromosome Mapping
MH  - Environment
MH  - Gene-Environment Interaction
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Immune System Diseases/*genetics/*metabolism
MH  - *Quantitative Trait Loci
MH  - *Signal Transduction
EDAT- 2013/08/07 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/08/07 06:00
PHST- 2013/08/07 06:00 [entrez]
PHST- 2013/08/07 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - nrg3502 [pii]
AID - 10.1038/nrg3502 [doi]
PST - ppublish
SO  - Nat Rev Genet. 2013 Sep;14(9):661-73. doi: 10.1038/nrg3502. Epub 2013 Aug 6.